Total Synthesis and Biological Assessment of Mandelalide A

Cascade reaction: Total synthesis of the marine macrolide mandelalide A (1) has been achieved from crotonaldehyde, (S)-1,2-O-isopropylideneglycerol, and l-rhamnose. Final assembly of the core...

Intramolecular Silicon-Assisted Cross-Coupling:  Total Synthesis of ( )-Brasilenyne

The first, total synthesis of ( )-brasilenyne (1) has been achieved in 19 steps from l-(S)-malic acid. The key elements of this approach are a highly diastereoselective ring-opening of a 1,3-dioxol...

Evolution of the Total Synthesis of (−)-Okilactomycin Exploiting a Tandem Oxy-Cope Rearrangement/...

An effective, asymmetric total synthesis of the antitumor antibiotic (−)-okilactomycin (1), as well as assignment of the absolute configuration, has been achieved exploiting a convergent strategy....

First total synthesis of taxol. 2. Completion of the C and D rings

Convergent, enantiospecific total synthesis of the novel cyclodepsipeptide ( )-jasplakinolide...

Tremorgenic Indole Alkaloids. The Total Synthesis of (−)-Penitrem D

A convergent, stereocontrolled total synthesis of the architecturally complex tremorgenic indole alkaloid (−)-penitrem D (4) has been achieved. Highlights of the synthesis include an efficient,...

A total synthesis of (. -.)-tirandamycin B

Total Synthesis of the Proposed Structure of Neaumycin B

Total synthesis of the proposed structure of neaumycin B was achieved in 22 steps (longest linear sequence) through acid-mediated spiroketalization and a combination of efficient C−C bond forming...

Divergent Total Syntheses of ( )‐Vulgarisins A–E

The asymmetric total syntheses of ( )-vulgarisins A–E, which share a rare [5-6-4-5] tetracyclic core structure, have been achieved for the first time in a divergent manner. Key features of the...

Total Synthesis of (−)-Laulimalide

(−)-Laulimalide (1), a structurally novel macrolide isolated in trace amounts from marine sponges, promotes abnormal tubulin polymerization and apoptosis in vitro, with a similar mode of action to...