Vibrio mimicus carrying the Type III Secretion System 2 (T3SS2) and TDH toxin of Vibrio parahaemo...

Objectives Identify possible virulence factors in the genomes of Vibrio mimicus that may be determinants of diarrheal cases/outbreaks. Methods All V. mimicus genomes from Genbank were retrieved and...

Burkholderia pseudomallei BopE suppresses the Rab32-dependent defense pathway to promote its...

B. pseudomallei is facultative intracellular bacterium that has evolved numerous strategies to evade host immune vesicles and survive in the cytoplasm. Rab32-dependent vesicles are one of these...

Distinct mechanisms of type 3 secretion system recognition control LTB4 synthesis in neutrophils...

Author summary The production of inflammatory lipid mediators by the host is essential for timely inflammation in response to invasion by bacterial pathogens. Therefore, defining how immune cells...

Phenotypic diversity of type III secretion system activity in enteropathogenic Escherichia coli...

A flagellar accessory protein links chemotaxis to surface sensing | Journal of Bacteriology

Bacterial biofilms pose a threat in clinical and industrial settings. Surface sensing is one of the first steps in biofilm formation. Studying surface sensing can improve our understanding of biofilm...

Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas...

Pseudomonas aeruginosa is one of the most prevalent etiological agents in healthcare-associated infections, especially in lower respiratory tract infections. As P. aeruginosa has frequently intrinsic...

The coming microbial crisis: Our antibiotic bubble is about to burst

This month, the United Nations (UN) General Assembly will convene its second High-Level Meeting on antimicrobial resistance, urging UN member states to take decisive action against this growing...

TYPE THREE SECRETION SYSTEM-INDUCED MECHANOPORATION OF VACUOLAR MEMBRANES

Endomembrane breaching is a crucial strategy employed by intracellular pathogens enclosed within vacuoles to access the nutrient-rich cytosol for intracellular replication. While bacteria use various...

The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenoty...

Bacteria in the chlamydiales order are obligate intracellular parasites of eukaryotic cells. Within this order, the genus Chlamydia contains the causative agents of a number of clinically important...

Yersinia pseudotuberculosis growth arrest during type-III secretion system expression is associated...

It has been long appreciated that expression of the Yersinia type-III secretion system (T3SS) in culture is associated with growth arrest. Here we sought to understand whether this impacts expression...

Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of...

These findings highlight the pathogenic significance of T3SSs in the context of CD and identify specific T3SS genes that could potentially function as biomarkers for diagnosing and monitoring the...

RNase-mediated reprogramming of Yersinia virulence

Author summary Bacterial pathogens need to quickly adapt the expression of virulence- and fitness-relevant traits in response to host defenses. Pathogenic Yersinia species rapidly upregulate a type...

Xanthomonas citri subsp. citri type III effector PthA4 directs the dynamical expression of a...

The putative carbohydrate-binding protein gene Cs9g12620 by PthA4-mediated induction of CsLOB1 during Xcc infection.

Commensal Yeast Promotes Salmonella Typhimurium Virulence

Enteric pathogens engage in complex interactions with the host and the resident microbiota to establish gut colonization. Although mechanistic interactions between enteric pathogens and bacterial...