@Tcomplex profile picture
John Schimenti @Tcomplex

Professor of Genetics at Cornell and Avid Golfer

Joined July 2009
  • Tweets 221
  • Following 79
  • Followers 417
38 Photos and videos
A terrific body of work by postdoc Munisha Mumingjiang and grad student Rui Huang on the impact of genomic instability on trophoblast stem cells and placenta development. Years in the making. biorxiv.org/content/10.1101/…

Chronic replication stress-mediated genomic instability disrupts placenta development in mice

Abnormal placentation drives many pregnancy-related pathologies and poor fetal outcomes, but the underlying molecular causes are understudied. Here, we show that persistent replication stress due to...

biorxiv.org
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A high throughput CRISPR perturbation screen identifies epigenetic regulators impacting primordial germ cell development biorxiv.org/content/10.1101/… We found that a histone deacetylase KD, and HDAC inhibitors (inc. a dietary supplement), impede PGCLC formation> somatic genes stay on

A high throughput CRISPR perturbation screen identifies epigenetic regulators impacting primordial...

Certain environmental factors can impact fertility and reproductive parameters such as the number and quality of sperm and eggs. One possible mechanism is the perturbation of epigenetic landscapes in...

biorxiv.org
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Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells biorxiv.org/content/10.1101/… If you need a ton of PGCLCs and don't want to use expensive cytokines in the process, you may find this method useful.

Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells

Primordial germ cells (PGCs) are the founder cells of the germline. The ability to generate PGC-like cells (PGCLCs) from pluripotent stem cells has advanced our knowledge of gametogenesis and holds...

biorxiv.org
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1 y.o. grand-daughter figures out how to make every putt!
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Our studies of why genetic variant pathogenicity prediction algorithms leave much to be desired: pnas.org/doi/10.1073/pnas.22…

In vivo versus in silico assessment of potentially pathogenic missense variants in human reproduc...

Infertility is a heterogeneous condition, with genetic causes thought to underlie a substantial fraction of cases. Genome sequencing is becoming in...

pnas.org
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Junior faculty positions at Cornell in reproduction!
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academicjobsonline.org/ajo/j… jcs92@cornell.edu (John Schimenti) pc242@cornell.edu (Paula Cohen)
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John Schimenti retweeted
New York Stem Cell Foundation Research Institute@nyscf
23 Sep 2022
Meet NYSCF – Druckenmiller Fellow @MominMunisa, #postdoc in the @Tcomplex lab @Cornell! Munisha studies the genetics behind #placenta development to help prevent #preeclampsia & #pregnancyloss: bit.ly/3TMMMqx #PostdocAppreciationWeek #PostdocAppreciation #WomeninSTEM
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John Schimenti retweeted
Carl Schimenti@Carl_Schimenti
23 May 2022
Come join us tomorrow! If it adds validity to my resume, My partner @turk727 and I won the @NYSGA1923 4-ball today at Leatherstocking GC. Shout out to @oneillrida92 and staff for a championship venue this week!
Micah Woods@asianturfgrass
23 May 2022
In the next ATC Office Hours (Tuesday, May 24, check your time zone), @Carl_Schimenti joins for a discussion of golf course playability and the maintenance work needed to produce the best conditions. youtu.be/2fMhNSEkpLI
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John Schimenti retweeted
Cornell University
@Cornell
7 Nov 2021
CornellALERT: EVACUATE AND AVOID THE LAW SCHOOL,GOLDWIN SMITH, UPSON HALL AND KENNEDY HALL PLEASE DO NOT CALL THE CORNELL POLICE UNLESS YOU HAVE AN EMERGENCY
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A firehose of variants, a few drops of validation.... biorxiv.org/content/10.1101/…

In vivo versus in silico assessment of potentially pathogenic missense variants in human reproduc...

Infertility is a highly heterogeneous condition, with genetic causes estimated to be involved in approximately half of the cases. High-throughput sequencing (HTS) approaches are becoming an increas...

biorxiv.org
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John Schimenti retweeted
Cornell MBG@CornellMBG
29 Sep 2021
Super excited to announce that MBG is searching for TWO new faculty members! Open topic - we're happy to receive applications from biologists working in any research area that spans the breadth of MBG. academicjobsonline.org/ajo/j…
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Quote from Tom Brady on getting older: “You think people care what you think, and then you care less what people think, and then you realize no one cared, anyway.”
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John Schimenti retweeted
New York State Golf Assoc.@NYSGA1923
26 Sep 2021
Our 2021 #NYSMensMidAm champion 🏆 Carl Schimenti (Cornell University GC) outlasted Chris Blyth (Locust Hill CC) in a two-hole playoff to win his first NYS title! Recap: bit.ly/3EW2pVe
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John Schimenti retweeted
Dr. Karen Schindler@KASchindler27
22 Aug 2021
With oocyte expertise from the extraordinary @BlenginiCecilia! She’s on the job market this fall folks and is a rising star!
Nature Communications@NatureComms
20 Aug 2021
The Schimenti lab model 8 human SNPs within mismatch repair genes to assess their impact on fertility in mice @Tcomplex @KASchindler27 go.nature.com/3xXE1Oc
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Please check out Mark Rober, a cool science YouTuber, giving a glimpse into autism. Being a parent of an autistic daughter, its nice to see his positive spin. The Truth About my Son youtu.be/ybPgmjTRvMo via @YouTube

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John Schimenti retweeted
Global News Trending@GNewsTrending
14 Apr 2021
Leaked footage of ‘pyramid-shaped’ UFOs is real, Pentagon says dlvr.it/RxgG05
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Spring snowstorm alert. I just put away my plow, snowblower and snow tires, virtually guaranteeing a blizzard in the next couple of weeks. Apologize in advance.
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John Schimenti retweeted
Rob Maurer
@robmaurer
15 Mar 2021
Elon Musk has a new title: Technoking of Tesla. Tesla CFO Zach Kirkhorn is now also Master of Coin. Yes, these are official titles, per a Tesla SEC filing this morning. @elonmusk $TSLA sec.gov/Archives/edgar/data/…

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