I predict we’re going to see a surge in “mystery” illnesses, autoimmune conditions, and even cancer in the coming years among people who have used GLP-1s. Not due to the GLP-1s themselves, but because losing mass amounts of fat in a short period of time can be detrimental to the body.
Fat tissue acts as a storage site for a wide range of compounds, including environmental toxins and heavy metals. When someone loses a massive amount of weight in a very short period of time, all of that has to be processed and eliminated somewhere. If nutrient intake is low, bowel movements are infrequent, liver function is already compromised, or overall metabolic health is poor, that’s a significant burden to place on the body all at once.
It would be a different conversation if people were using low doses, losing weight gradually, maintaining adequate nutrition, and supporting detoxification pathways, but that’s often not what’s happening. I personally know multiple people who lost 30 pounds in a single month. Their overall health has suffered dramatically since.