@TheYaoLab profile picture
The Yao Lab @TheYaoLab

Reproductive & Developmental biologists interested in everything related to sex differentiation from gonads to genitalia. Tweets are mine. 🇹🇼🇺🇸🇫🇷🇵🇪🇦🇷

Joined August 2017
  • Tweets 55
  • Following 180
  • Followers 473
6 Photos and videos
Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation | Science Advances science.org/doi/10.1126/scia…

Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying...

Sex-specific changes in chromatin and gene expression underlie the divergent development of the bipotential gonadal primordium.

science.org
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The Yao Lab@TheYaoLab
15 Jul 2025
Check out our new paper in Biology of Reproduction that describes the Generation of a Nr2f2-driven inducible Cre mouse to target interstitial cells in the reproductive system. academic.oup.com/biolreprod/…

Generation of a Nr2f2-driven inducible Cre mouse to target interstitial cells in the reproductive...

Abstract. The orphan nuclear receptor Nr2f2, also known as COUP-TFII, plays important roles in the development and function of multiple organs, including t

academic.oup.com
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The Yao Lab@TheYaoLab
29 Apr 2025
Very excited with our new Nature Communications paper on fetal Leydig cell differentiation. NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differences of sex devel… pubmed.ncbi.nlm.nih.gov/4029…

NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differ...

Testicular fetal Leydig cells produce androgens essential for male reproductive development. Impaired fetal Leydig cell differentiation leads to differences of sex development including hypospadias,...

pubmed.ncbi.nlm.nih.gov
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An extragenital cell population contributes to urethra closure during mouse penis development | Science Advances science.org/doi/10.1126/scia… Exited to share our new paper that shed light on development of male external genitalia, or penis, 陰莖, wennie, pene, 음경, or ペニス😊😅😉

An extragenital cell population contributes to urethra closure during mouse penis development

An extragenital cell population facilitates penis development and proper urethra closure in mouse embryos.

science.org
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The Yao Lab@TheYaoLab
13 Aug 2024
We have a biologist position available in the lab. Candidates must have a master or PhD degree with US citizenship, and familiar with mouse genetic models, imaging techniques, single cell sequencing, and bioinformatics. If you are interested, email me at humphrey.yao@nih.gov
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Our new technique is published in BOR, check it out: New uses for an old technique: live imaging on the slice organ culture to study reproductive processes academic.oup.com/biolreprod/…

New uses for an old technique: live imaging on the slice organ culture to study reproductive...

Summary Sentence Overall, using slice culture methods with live imaging will help researchers uncover biological processes within reproductive organs.

academic.oup.com
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Congratulations to my post-doctoral fellow Ciro Amato for winning the 2022 NIEHS Fellow of the Year Award! factor.niehs.nih.gov/2023/1/…

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The Yao Lab@TheYaoLab
28 Nov 2022
Enjoy our new paper by Kamiya Bridges and @docteurbarb: Loss of Runx1 Induces Granulosa Cell Defects and Development of Ovarian Tumors in the Mouse mdpi.com/1957678 #mdpiijms via @IJMS_MDPI

Loss of Runx1 Induces Granulosa Cell Defects and Development of Ovarian Tumors in the Mouse

Genetic alterations of the RUNX1 gene are associated with a variety of malignancies, including female-related cancers. The role of RUNX1 as either a tumor suppressor gene or an oncogene is tissue-d...

mdpi.com
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The Yao Lab@TheYaoLab
12 Nov 2022
Sperm-Blocking Gel Implant "Could Be A Game-Changer" For Male Contraception iflscience.com/sperm-blockin…

Sperm-Blocking Gel Implant "Could Be A Game-Changer" For Male Contraception

The gel could be a less invasive alternative to a vasectomy, also dissolving after two years.

iflscience.com
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The Yao Lab@TheYaoLab
11 Nov 2022
Opinion: In Publishing, Don’t Make the Perfect the Enemy of the Good the-scientist.com/news-opini…
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Congratulations to my post-doc Adriana Alexander for receiving this inaugural award! faseb.org/journals-and-news/…

FASEB
@FASEBorg
3 Nov 2022
FASEB announces the recipients of its inaugural CARES Awards. The award helps alleviate the financial burdens associated with caregiving. Each recipient received a $5,000 award. Join us in congratulating the awardees! bit.ly/3T8Yqdz
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Your 2022 NIEHS Trivia winner is…. 🥁🥁🥁 “Generation Next” from the Yao lab!
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The Yao Lab retweeted
The Nobel Prize
@NobelPrize
3 Oct 2022
BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”
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The Yao Lab@TheYaoLab
30 Sep 2022
2022 Capel & Yao Lab Retreat! Great science, data sharing, and friendship! Kudos to Adriana Alexander and Talia Hatkevich @t_money_h for organizing such a wonderful gathering!
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The Yao Lab@TheYaoLab
30 Sep 2022
We miss you, Ceri! Hope everything is doing well for you!
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The Yao Lab@TheYaoLab
23 Sep 2022
This is a trend we all need to make the efforts to break. Diversity is not just about gender, race, etc! Most US professors are trained at same few elite universities nature.com/articles/d41586-0…

Most US professors are trained at same few elite universities

Nature - ‘Jarring’ study reveals hiring bias at US institutions.

nature.com
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The Yao Lab retweeted
PHD Comics@PHDcomics
22 Sep 2016
Happy Postdoc Appreciation Week - Read all the postdoc comics here: phdcomics.com/comics.php?f=1…
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The Yao Lab retweeted
VSD Hawaii@VsdHawaii
19 Sep 2022
🌺Aloha🌺 The 9th International Symposium on the Biology of Vertebrate Sex Determination will be held in person at Courtyard King Kamehameha’s Kona Beach Hotel in Kona, Hawaii on April 17-21, 2023. For more information check out the website vsd-hawaii.com
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The Yao Lab@TheYaoLab
14 Sep 2022
Hot off the press: our new publication with my former post-doc @feizhao10 in PNAS Nexus: Contribution of the Wolffian duct mesenchyme to the formation of the female reproductive tract academic.oup.com/pnasnexus/a…

Contribution of the Wolffian duct mesenchyme to the formation of the female reproductive tract

Abstract. The female reproductive tract develops from its embryonic precursor, the Müllerian duct. In close proximity to the Müllerian duct lies the precur

academic.oup.com
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Take a look at our new review that led by Staff Scientist @docteurbarb: "Becoming female: Ovarian differentiation from an evolutionary perspective" frontiersin.org/articles/10.…

Frontiers | Becoming female: Ovarian differentiation from an evolutionary perspective

Differentiation of the bipotential gonadal primordium into ovaries and testes is a common process among vertebrate species. While vertebrate ovaries eventual...

frontiersin.org
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