mapping gene networks to enable network-based therapeutic discovery in cardiovascular disease
Joined September 2022
- Tweets 46
- Following 51
- Followers 603
- Likes 14
18 Photos and videos
Happy to share a protocol for discovery of candidate therapeutic targets with Geneformer by @YujieZh1729!
Nature Protocols link: rdcu.be/ffApo
Google Colab: tinyurl.com/geneformertutori…
6
26
2,718
Really enjoyed talking with science journalist Andrew Han about art and science on his new podcast, Ion Genomics! Check it out here: iongenomics.bio/p/podcast-ep…
3
147
Excited to share MaxToki, a temporal AI model that predicts the impact of perturbations on cell states over time along dynamic trajectories. We applied MaxToki to predict how cells age across the human lifespan & discovered new cardiac pro-aging drivers that we validated in vivo.
1
10
30
7,142
Manuscript: tinyurl.com/maxtoki
Press release: gladstone.org/news/new-ai-mo…
Model: huggingface.co/theodoris-lab…
Code: github.com/NVIDIA-Digital-Bi…
Blog post: theodorislab.gladstone.org/p…
1
2
302
Thank you to the whole team for their wonderful collaboration on this work! Javier Gόmez Ortega, @alexis_combes, @andcyang, @StefanieDimmel1, Shinya Yamanaka, @m_alexanian, @NVIDIAHealth
242
Mar 27
Congrats to @hanimal725 and @madhavanvvs for their work in Nature Computational Science that demonstrated scaling laws for foundation models for network biology and implemented a quantization approach to enable resource-efficient predictions! rdcu.be/famFk
1
5
328
Mar 27
Thank you to the whole team on this collaboration: Javier Gómez Ortega, @Sid_Mahesh_12, Tarak Nandi, @madduri, and @PelkaLab!
129
19 Aug 2024
We are excited to share work led by @hanimal725 and @madhavanvvs developing a quantized multitask learning strategy for network biology, built on a foundation model pretrained on ~95M single-cell transcriptomes.
Manuscript: tinyurl.com/qmtl-gf
Model: huggingface.co/ctheodoris/Ge…
2
11
54
7,447
19 Aug 2024
Overall, quantized multi-task learning enables resource-efficient context-specific modeling in gene network biology to yield contextual predictions of key network regulators and candidate therapeutic targets for human disease.
1
512
19 Aug 2024
Thank you to the whole team for the wonderful collaboration! Javier Gómez Ortega, @Sid_Mahesh_12, Tarak Nandi, @madduri, and @PelkaLab!
x.com/TheodorisLab/status/18…
19 Aug 2024
We are excited to share work led by @hanimal725 and @madhavanvvs developing a quantized multitask learning strategy for network biology, built on a foundation model pretrained on ~95M single-cell transcriptomes.
Manuscript: tinyurl.com/qmtl-gf
Model: huggingface.co/ctheodoris/Ge…
1
1
2
618