Molecular Biologist, DNA repair, sirtuins, ageing and Neurodegeneration
Joined March 2017
- Tweets 279
- Following 326
- Followers 470
- Likes 1,142
27 Photos and videos
Feb 19
Why'd you have to go and make things so complicated? Simplicity as a Lens: A New Way to Model Brain Aging. biorxiv.org/content/10.64898… our latest preprint! #AgingResearch #Neuroscience #Alzheimers #SIRT6 #biotech
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Feb 19
Congratulations to Yuval, the leading author, and all our collaborators: Dmitrii Smirnov, Songchen Yang, Daniel Stein, Zeev Slobodnik,
@EremenkoEkater2
Shai Kaluski-Kopach, Monica Einav, and Ekaterina Khrameeva
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Feb 19
Why'd you have to go and make things so complicated?
Simplicity as a Lens: A New Way to Model Brain Aging.
biorxiv.org/content/10.64898…
See our latest preprint!
#AgingResearch #Neuroscience #Alzheimers #SIRT6 #BioTech
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Feb 19
Congratulations to Yuval, the leading author, and all our collaborators: Dmitrii Smirnov, Songchen Yang, Daniel Stein, Zeev Slobodnik, @EremenkoEkater2 Shai Kaluski-Kopach, Monica Einav, and Ekaterina Khrameeva
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Feb 18
SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling - Stein - 2026 - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/…
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Debbie Toiber retweeted
Jan 27
Genluminati follows a group of young scientists who invent a DNA-based religion as a cynical experiment—only to lose control of it when belief spreads, and a prophet emerges. Did the concept begin as #satire for you, or did you always see it turning dark?
wp.me/p3cyvH-LYH?utm_campaig…
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Jan 23
Check out this book recommendation from Literary_Titan: bookbub.com/reviews/20329201… via @Bookbub
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7 Dec 2025
SIRT6 decline throws Off Mood, Sleep, and Cognition.
rdcu.be/eTvJj
Tryptophan byproducts build proteins, NAD , and neurotransmitters (serotonin and melatonin). Yet, in aging and neurological disease, this balance is lost, leading to impaired mood, learning, and sleep.
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7 Dec 2025
Crucially, we show that this damage isn't permanent. By inhibiting the enzyme TDO2 in our SIRT6 knockout fly model, we were able to significantly reverse both neuromotor decline and vacuolar formation, indicating a powerful therapeutic window.
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7 Dec 2025
This positions SIRT6 as a critical, upstream drug target for combating neurodegenerative pathology.
Amazing work by Shai Kaluski-Kopatch, and collaborators
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Debbie Toiber retweeted
18 Nov 2025
what am I up to? reading @ToiberDebbie 's new book of course
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3 Nov 2025
GENLUMINATI is now available!
In this work of fiction, a group of university friends studying biology becomes obsessed with the idea of creating a religion based on “reading your own genome to achieve enlightenment.”
Kindle lnkd.in/dBgqFPBm
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3 Nov 2025
They turn it into a social experiment, testing people’s faith. The book explores their lives as PhD students doing research and as the masterminds behind a new religion, delving into moral and ethical dilemmas when things spiral out of control. Paperback lnkd.in/dUeyR9Mx
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Debbie Toiber retweeted
29 Sep 2025
Link to the episode on Spotify open.spotify.com/episode/2br…
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Debbie Toiber retweeted
18 Oct 2025
We’re excited to unveil our new joint work (with @ToiberDebbie and many fantastic collaborators) on how pharmacological activation of SIRT6 (via MDL-800) reshapes tumor metabolism and blocks tumor growth in HNSCC & ESCC models. @SpringerNature rdcu.be/eLBPC
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Debbie Toiber retweeted
24 Oct 2025
🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive article written with @ToiberDebbie how we can target the most fundamental mechanisms of aging and cancer. @AnnualReviews 🔗 go.shr.lc/3JohYMp
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