Moved to ivatolic.bsky.social! Biophysics of Mitosis @institutrb, @EMBO member; Ex Group Leader @mpicbg, PD @UNI_FIRENZE, @uni_copenhagen, PhD @PMFZAGREB
Joined June 2018
- Tweets 1,118
- Following 856
- Followers 3,305
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450 Photos and videos
Iva Tolić retweeted
Jun 11
Why 50% of human fertilized eggs fail to complete pre-implantation development?
Latest work from my lab in @CellCellPress now clarifies the two causes that contribute to the low efficiency of early human embryos and provides one of the solutions. (1/7)
doi.org/10.1016/j.cell.2026.…
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Beyond thrilled to share that I've been elected as a member of the Croatian Academy of Sciences and Arts (HAZU)! Deeply grateful to my group at @institutrb, collaborators, mentors, and family, I didn't get here alone. Photo is from my associate membership, a new one coming soon!
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Our third Swiss-Croatian Bilateral Project meeting in Split, with @LabMeraldi, @nenad_pavin, and special guest @Ivana_Gasic! Great science and plenty of exciting new ideas to explore! @hrzz_science @snsf_ch 🇭🇷🇨🇭
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We love @SrceHr (“Srce” means “Heart”), our University Computing Center and an amazing collaborator! It was great to give a talk at "Days of e-Infrastructure" and celebrate SRCE’s 55th anniversary. Happy birthday, SRCE! 🎉 #SrceDEI2026
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Iva Tolić retweeted
May 8
We are looking to recruit two highly enthusiastic and motivated research fellow to work on Plasmodium cell division (unusual mitosis and meiosis). Funded by @ERC_Research ;@BBSRC. please apply below .
jobs.nottingham.ac.uk/MED459…
jobs.nottingham.ac.uk/MED482…
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What an inspiring few days in Dubrovnik at #SpindleCroatia2026, which @nenad_pavin and I organized for the 4th time. Outstanding science and many warm reunions with colleagues from around the world! Huge thanks to the whole spindle community!!
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In the closing talk of #SpindleCroatia2026, Helder Maiato @mitosisrocks discussed how dividing cells adapt to karyotype evolution. Using Indian muntjac (2N=6/7) and Chinese muntjac (2N=46) cells, they showed that high chromosome number is a critical mitotic vulnerability.
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Monica Gobran @LenartLab showed that when CDK1 is partially inhibited, nuclear pores begin to disassemble, but the overall structure of the nuclear envelope remains intact, similar to closed mitosis. The spindle forms outside the nucleus. #SpindleCroatia2026
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Jacques Pécréaux used FRAP of the half-spindle in C. elegans and revealed that only kinetochore microtubules exhibit flux, sliding along pole-anchored ones. The flux is larger on the posterior side, reflecting the imbalance in cortical pulling forces. #SpindleCroatia2026
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Régis Giet @RegisGiet showed that, in Drosophila neural stem cells, the number of astral microtubules nucleated by each centrosome determines the spindle position. Asymmetric pushing forces, rather than cortical pulling, dominate spindle positioning. #SpindleCroatia2026
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Arp Schnittger examined kinetochores in plant meiosis, focusing on how mono‑orientation of sister kinetochores is achieved in plants. Arabidopsis has a homolog of Csm1, a monopolin component, with a function in kinetochore organization and mono‑orientation. #SpindleCroatia2026
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Gautam Dey @Dey_Gautam discussed spindle evolutionary dynamics. In Chlamy, an MTOC forms in prophase to nucleate the spindle, but remains tethered to the basal bodies. By using ExM, they plan to expand every microbial eukaryote on Earth! #SpindleCroatia2026
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Marija Žanić @ZanicLab used EB1 imaging to determine the relationship between microtubule GTP-cap size and growth rate throughout the cell cycle. GTP-cap size for matching growth rates drops during mitosis, suggesting active regulation of the hydrolysis rate. #SpindleCroatia2026
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Ana Pinto Teixeira showed that excessive MPS1 activity drives CIN by promoting an untimely expansion of the fibrous corona, providing a structural basis for merotely and chromosome missegregation in colon cancer. #SpindleCroatia2026
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Verena Cmentowski explored the mechanism that triggers dynein activation at kinetochores. CENP‑E facilitates the recruitment of dynein-dynactin and cofactors to kinetochores and regulates dynein motility. #SpindleCroatia2026
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Tarun Kapoor developed a chemical genetic approach to analyze the functions of VPS4, a key protein required for nuclear envelope repair in human cells. Upon VPS4 inhibition, CHMP7 persists, and inner nuclear membrane defects form, leading to DNA damage. #SpindleCroatia2026
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Julie Welburn discussed the molecular basis for how PRC1 recruits CENP-E to the central spindle in anaphase. She also explored how drug binding varies with beta-tubulin isotypes, showing that human meiotic beta8-tubulin has a reduced sensitivity to nocodazole. #SpindleCroatia2026
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