Drug Development | MD DPhil (Ox) | Ex-VC Fellow @ArtisVentures
Joined May 2023
- Tweets 35
- Following 195
- Followers 78
- Likes 93
1 Photos and videos
Tom Thomas retweeted
22 Oct 2024
Why do some inflammatory bowel disease patients benefit from anti-TNF therapy whilst others do not?
Our new @NatImmunol resource paper investigates this question by following patients before and after treatment: nature.com/articles/s41590-0… 👇
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Tom Thomas retweeted
20 May 2023
The career question I get asked the most is “why did I become a Physician-Scientist” - too often I give a vanilla answer to this - some colleagues have a Eureka moment- for me it was uncertainty, failure & extraordinary mentorship that set me on my journey nature.com/articles/s43018-0…
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Tom Thomas retweeted
19 May 2023
NICE says genetic testing before initiating clopidogrel is a cost-effective use of NHS resources for patients at risk of stroke
pharmaceutical-journal.com/a…
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Tom Thomas retweeted
18 May 2023
Today's #JEMLegacy @JExpMed highlights the work of Fiona Powrie @powrie_lab & colleagues showing #Treg cells constitutively express #CTLA-4 and signaling via CTLA-4 is essential for their function to control intestinal inflammation. doi.org/10.1084/jem.192.2.29…
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Tom Thomas retweeted
19 May 2023
Proud to be part of Dexter, as a tool for clinical trials. Dexter can help with quality improvement, predictive analytics and informatics consult in addition to observational studies and clinical trials. @KrishnaGokhale @UoB_IAHR @HDR_UK @JohtChandan
19 May 2023
Proud to celebrate #CTD2023
@unibirmingham has a strong heritage in innovation and clinical trial research. Professor Krish @Nirantharakumar explains how a new software called Dexter can benefit patients by fine-tuning clinical trial design. More at bit.ly/45af6J5
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Tom Thomas retweeted
19 May 2023
Please check out my paper on healthy synovial fibroblasts and the role of cortisol signaling, now on Bioarchive. Much thanks to all my co-authors!! @ilyakorsunsky
@lynchielydia @AHelenaJonsson1 @FanZhang_Jessie @soumya_boston biorxiv.org/content/10.1101/…
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Tom Thomas retweeted
16 May 2023
Do T cells remember what we eat? In @JExpMed, Lockhart, @danmucida et al @RockefellerUniv show that physiological exposure to food protein drives CD4 T cell accumulation, clonal selection, and transcriptional adaptation at the intestinal epithelium. bit.ly/458bZS3
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Tom Thomas retweeted
10 May 2023
Excited to share another Bioinformatician position in our lab based on our recent fundings!! Great opportunity to develop computational AI methods for longitudinal #SingleCell omics for translational medicine! cu.taleo.net/careersection/2… @CUBiomedInfo @CURheumatology DM me directly🙌
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Tom Thomas retweeted
9 May 2023
To celebrate the release of THE BOOK THAT WOULDN'T BURN...
...everyone who retweets this g̷e̷t̷s̷ ̷a̷ ̷c̷a̷r̷ ... I mean is in the draw for a signed, dedicated copy ... I'll even number it for you!
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10 May 2023
Similar scale work needed in the Indian subcontinent as well given rising incidence rates!
10 May 2023
Congrats on this groundbreaking work!!! @BDYE_IBD #HosuLee #KyuyoungSong @doc_ibd @JudyCho7 @AsanIbd @NatureGenet nature.com/articles/s41588-0…
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Tom Thomas retweeted
9 May 2023
Fascinating new preprint on bioRxiv tackles a whale of a question:
Whales are huge. So why don’t they get a ton of cancers?
biorxiv.org/content/10.1101/…
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Tom Thomas retweeted
9 May 2023
Very happy to announce that today two papers on #PhIPSeq in (1) the general population (🧵 by @sea_andreu) and (2) in patients with inflammatory bowel diseases (#IBD), got published today in @ImmunityCP authors.elsevier.com/c/1h2md…
doi.org/10.1016/j.immuni.202… 🧵 on IBD findings:
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Tom Thomas retweeted
24 Apr 2023
Delighted to share our paper on mitochondrial dynamics in B cells and lymphoma. Really grateful to my supervisor @a_j_clarke for his invaluable support and mentorship. Huge thanks to my co-supervisor @MichaelLDustin, collaborators and colleagues @KirOxford & @UniofOxford
24 Apr 2023
Clarke and colleagues find that B cells require TFAM for their development and transcriptional and spatial entry into the GC reaction by modulating cellular motility. Read it here: rdcu.be/daDaj @a_j_clarke @KirOxford @YavuzYaziciogl1
nature.com/articles/s41590-0…
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Tom Thomas retweeted
5 May 2023
#Macrophages in the synovial lining niche initiate #neutrophil recruitment and articular #inflammation, say Kristina Zec, Irina Udalova et al. @UdalovaLab @KirOxford bit.ly/3LD9qzx
#arthritis
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9 May 2023
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Tom Thomas retweeted
8 May 2023
We are thrilled to share the first publication from the McAlpine lab! Out today in @ImmunityCP.
“Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis”
@IcahnMountSinai @SinaiHeartBlood @SinaiBrain
cell.com/immunity/fulltext/S…
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Tom Thomas retweeted
7 May 2023
Wow... 80% of genes are differentially expressed in living versus post-mortem prefrontal cortex tissue. Importantly implications for studying the 'living' biology of the human brain, rather than heavy reliance on what post-mortem tissue shows us. medrxiv.org/content/10.1101/…
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7 May 2023
Longitudinal scRNAseq in biologic naive patients with IBD - adalimumab:
biorxiv.org/content/10.1101/…
This work was made possible by patients and clinical colleagues at the TGU(Oxford), QEHB(Bham), colleagues @KirOxford,@HumanGeneticsOx ,@celsiustx who helped deliver despite COVID
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7 May 2023
Many thanks to Charlotte Rich-Griffin, Mathilde Pohin, Matthias Friedrich,@DominikAschenb2
@a_filer,@powrie_lab, Holm Uhlig, Simon Travis, @CalliDendrou, @arthritisbham and colleagues
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7 May 2023
Also worth checking out some other pre-prints! biorxiv.org/content/10.1101/…
biorxiv.org/content/10.1101/…
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