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Simon Trowitzsch @TrowitzschLab
Joined October 2020
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  • Following 43
  • Followers 63
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Check out our fresh review on TSEN biology brought together by the @TheHayneLab, @RobinStanleyLab, @TrowitzschLab, and @vanHooligans now available at JBC jbc.org/article/S0021-9258(2…!

New insights into RNA processing by the eukaryotic tRNA splicing endonuclease

Through its role in intron cleavage, tRNA splicing endonuclease (TSEN) plays a critical function in the maturation of intron-containing pre-tRNAs. The catalytic mechanism and core requirement for...

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It is finally out! Our cryo-EM structure of human TSEN in complex with pre-tRNA was just published in NSMB rdcu.be/ddBJH! Flattered to see the News&Views article by Anita Hopper & Jinwei Zhang rdcu.be/ddBJd! Thanks to everyone involved!

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Congratulations to Ines Müller and all others involved in this beautiful crystallographic work on a transient MHC-I chaperone complex published in Nature Communications! rdcu.be/cVyWI 👍
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Happy to share our work on the cryo-EM structure of human tRNA splicing endonuclease TSEN bound to substrate (biorxiv.org/cgi/content/shor…). Our reconstruction helps rationalize mutants that lead to pontocerebellar hypoplasia. A big 'thank you' to everyone involved in this study!

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Hurray! First paper of the TrowitzschLab out now in Nature Communications. A big thank you to everyone involved in this exciting contribution. rdcu.be/cyAT5
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