A new study shows that a combination of two cheap and widely available anti-rheumatic drugs (#leflunomide and #hydroxychloroquine) offers the first effective treatment for patients with #Sjögren’s disease with systemic disease activity.
Read more here: edu.nl/nqrhv
ALT ESSDAI scores over 24 weeks of treatment with leflunomide–hydroxychloroquine or placebo: (A) Mean ESSDAI corrected for baseline, indicating the treatment effect of leflunomide–hydroxychloroquine versus placebo after 8 weeks, 16 weeks, and 24 weeks. Error bars indicate SEM. (B) Within-treatment paired ESSDAI differences between baseline and 24 weeks, with each line representing one patient. p values indicate the difference compared with baseline
Researchers at @UMCUtrecht have discovered an underappreciated way in which immune cells quickly respond to infections. With longread RNA sequencing, they show that ‘alternative RNA splicing’ plays an important role in shaping #immune responses
read more: edu.nl/bvmtc
ALT From left to right: PI Jorg van Loosdregt, first author Alejandra Bodelón and co-PI Bas Vastert
Het @UMCUtrecht heeft een promotieplek voor een arts-onderzoeker binnen Reumatologie & Klinische Immunologie voor klinisch onderzoek naar moeilijk behandelbare reumatoïde artritis en vroege detectie van antistofdeficiëntie.
Sluit op 31/7.
Meer info hier: edu.nl/4ymeh
At @UMCUtrecht we have a position for a postdoc in IgA-like antibody development. You wil be involved in development, optimization and scale-up of IgA antibody production platforms, and next-generation antibodies (deadline 4/6).
Read more at edu.nl/r6dba
Interplay between gut bacteria and a deficiency of the virus-neutralizing #antibody IgA may play a role in children that have recurrent tespiratory tract infections, research from @radboudumc and @UMCUtrecht shows.
Read more: edu.nl/yg9ax
Het @UMCUtrecht heeft een promotieplek voor een arts-onderzoeker binnen Reumatologie & Klinische Immunologie, gericht op klinisch onderzoek naar moeilijk behandelbare reumatoïde artritis en vroege detectie van antistofdeficiëntie.
Meer info hier: edu.nl/fgjbr
Coordinated by @UMCUtrecht, researchers are developing a ecosystem that facilitates the conduct of clinical studies in general practice and a warm-base research infrastructure that can be rapidly employed in case of future outbreaks of #infectiousdiseasesedu.nl/mhy3y
A study coordinated by @UMCUtrecht and @Amsterdamumc shows that antibodies from Long COVID patients can induce persistent pain-like symptoms in mice. These findings provide evidence for a potential causal role of autoantibodies in Long Covid.
Read more: edu.nl/uf8gf
At @UMCUtrecht, for the first time in the Netherlands a patient with #systemicsclerosis has been treated with CAR T cell therapy. This opens a whole new perspective, not only for systemic sclerosis but also for other #autoimmune disorders.
Read more: edu.nl/xmw8y
A study by @UMCUtrecht and @UnivOxford reports that point-of-care testing alone does not reduce antibiotics use for respiratory infections in primary care. This indicates that testing should be embedded within broader antimicrobial stewardship strategies edu.nl/byd9b
At @CTI_UMCUtrecht we have a Principal Investigator position where you will lead your innovative, technology-focused research line, expand the department's computational immunology core, and drive large-scale, data-driven research projects
More info here: edu.nl/47m9w
Could brain signals guide a cure for epilepsy?
Maeike Zijlmans @UMCU_Intl aims to improve how surgeons identify epileptic tissue during operations, using advanced EEG biomarkers to help increase the chances of seizure-free outcomes.
🔗 bit.ly/3MIbfyw@CORDIS_EU
An analysis of the Dutch PRIMA-cohort did not find a relation between maternal diet during breastfeeding and the occurrence of eczema or food allergy during the first year of life, said fresh PhD Anneke Hellinga in her thesis at @CTI_UMCUtrecht
Read more: edu.nl/b69kr
Human gut #bacteria (#microbiome) can directly deliver proteins into human cells thereby actively shaping immune responses. This was found in a study led by @HelmholtzMunich, with participation from international partners including @UMCUtrecht.
More here: edu.nl/97cnd
PhD research by Lisa Hessels (@UMCUtrecht & Noordwest Ziekenhuisgroep) shows the evolving nature of #CAP and pneumococcal serotypes. She calls for better diagnostics, surveillance, and smarter biomarker use to improve patient care edu.nl/rpkgq#InfectiousDiseases
PhD research by Bastiaan van der Roest at @UMCUtrecht enhanced mathematical modeling to integrate multiple introductions and contact data. The model allows for a deeper understanding of how important multiple contact events are for virus transmission
More: edu.nl/k7yde
Not only the presence, but also the spatial organization and activity of #immune cells are critical determinants of #cancer progression. These findings were presented by Matthijs Baars (@UMCUtrecht) in his PhD thesis that he defended on January 6, 2026 edu.nl/k4mte
A grant of 4 million euros has been awarded by the Dutch National Healthcare Institute and #ZonMw to @UMCUtrecht to develop a clinical study with a customized therapy with #bacteriophages for patients with recurrent urinary tract infections.
More here: edu.nl/fg9wj
ALT Electron microscopic image of a Klebsiella targeting bacteriophage
PhD candidate Coco Beudeker, MD at @UMCUtrecht investigated how modified #antibodies can improve immune activation in premature neonates. Her research provides guidance for the development of antibody-based therapies to protect #neonates against #sepsisedu.nl/nc469
PhD research by Marjelle van Driel at @UMCUtrecht shows a critical 2–4 week window after surgery where early signs of chronic postsurgical pain emerge. Key predictors: high pain intensity, painful cold sensations, pre-op opioids & bone surgery
Read more: edu.nl/npkhe