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Walczak Lab @WalczakLab
Joined June 2015
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We're thrilled to share our new @J_A_C_S publication revealing how N-glycosylation shapes tau protein behavior. Check it out at pubs.acs.org/doi/10.1021/jac…

Chemical Synthesis Reveals Pathogenic Role of N-Glycosylation in Microtubule-Associated Protein Tau

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of tau protein aggregates. In this study, we investigated the effects of N-glycosylation on tau, focusing on...

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A warm welcome to the first-year graduate students joining the Walczak lab - Himanshu, Zachary, Tania, Cat, Lily and Antawn!
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We’re excited to share that our latest paper is officially published in its final form at @ACSCentSci! Huge thanks to everyone involved in making this work possible. pubs.acs.org/doi/10.1021/acs…

Post-Translational Modifications Control Phase Transitions of Tau

The self-assembly of Tau into filaments, which mirror the structures observed in Alzheimer’s disease (AD) brains, raises questions about the role of AD-specific post-translational modifications...

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A new paper in @J_A_C_S describing the synthesis of Si-linked glycomimetics. Congratulations to @i_am_santosh, Timmy, Nick and Kyle! pubs.acs.org/doi/10.1021/jac…
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Congratulations Kyle Fisch for receiving the NSF GRFP! Excited for the discoveries and impact you'll make in grad school and beyond. @CUBoulder @CUBoulderCHEM
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Our group's latest research on tetrahydroxydiboron-mediated reactions in peptide/protein chemistry is now published in @JOC_OL. A huge congrats to @Jing_Ruiheng! pubs.acs.org/doi/10.1021/acs…

Peptide and Protein Desulfurization with Diboron Reagents

In this Letter, we report a direct and robust desulfurization method employing water-soluble phosphine, specifically tris(2-carboxyethyl)phosphine hydrochloride (TCEP), and tetrahydroxydiboron...

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A new pre-print from our lab available on @biorxivpreprint Post-Translational Modifications Control Phase Transitions of Tau biorxiv.org/content/10.1101/…

Post-Translational Modifications Control Phase Transitions of Tau

The self-assembly of Tau(297-391) into filaments, which mirror the structures observed in Alzheimer’s disease (AD) brains, raises questions about the role of AD-specific post-translational modifica...

biorxiv.org
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Happy New Year from everyone at the Walczak Lab! Wishing you all a year of prosperity, both professionally and personally. 🥳🎉🥳
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Only two weeks left to apply to our graduate program at @CUBoulderCHEM! colorado.edu/chemistry/gradu…

Admissions

The Department of Chemistry is internationally recognized for our research and education. As part of a commitment to continuing this tradition of excellence,

colorado.edu
Walczak Lab@WalczakLab
21 Sep 2023
Join our virtual Open House on October 26th to explore our vibrant graduate program. Please help spread the word by sharing this invitation.🌟@CUBoulderCHEM @CUBoulder tinyurl.com/CUCHEM23
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We're excited to reveal our latest study on desulfurative borylation in @J_A_C_S ! Congrats to @Jing_Ruiheng, @wyattpowel87711, and Kyle! doi.org/10.1021/jacs.3c09081

Desulfurative Borylation of Small Molecules, Peptides, and Proteins

We introduce a direct conversion of alkyl thiols into boronic acids, facilitated by a water-soluble phosphine, 1,3,5-triaza-7-phosphaadamantane (PTA), in conjunction with tetrahydroxydiboron (B2(OH...

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Today we report in @J_A_C_S the first chemical synthesis of microtubule-associated protein tau. Congratulations to @wyattpowel87711 and @Jing_Ruiheng on this monumental accomplishment. 🎉👏 #TauSynthesis 1/n doi.org/10.1021/jacs.3c07338

Chemical Synthesis of Microtubule-Associated Protein Tau

Deposits of the microtubule-associated protein Tau (MAPT) serve as a hallmark of neurodegenerative diseases known as tauopathies. Numerous studies have demonstrated that in diseases such as Alzheim...

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Tau undergoes extensive post-translational modifications, but what truly stands out is the contrasting expression of these modifications in healthy and Alzheimer's afflicted brains. 🧠💡
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Stay tuned as we unveil more results and delve into intricate mechanistic studies.
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Our approach to investigate PTMs in tau revolves around chemical synthesis. We successfully combined 11 distinct fragments through a sequence of highly efficient ligations to produce the longest 2N4R isoform.
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Join our virtual Open House on October 26th to explore our vibrant graduate program. Please help spread the word by sharing this invitation.🌟@CUBoulderCHEM @CUBoulder tinyurl.com/CUCHEM23
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TMEM106B Fibrils from FTLD Patients and Healthy Controls | ACS Chemical Neuroscience pubs.acs.org/doi/full/10.102…
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Walczak Lab retweeted
CU Boulder 🦬
@CUBoulder
18 Jul 2023
Marvin H. Caruthers, distinguished @CUArtsSciences professor, has won the inaugural $400,000 Richard N. Merkin Prize in Biomedical Technology! 💛 🖤 Congratulations! 🎉 Read more below! ⬇️
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Thank you @CUArtsSciences for highlighting our recent work in neurodegeneration! colorado.edu/asmagazine/2023…

Chemist to study molecular inner workings of Alzheimer’s disease

Maciej Walczak, CU Boulder associate professor of chemistry, won a $2 million NIH grant to investigate how certain sugars modify a brain protein associated with

colorado.edu
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🎉Congratulations to @wyattpowel87711 for winning best poster award at 2023 @ampepsoc meeting in Scottsdale, AZ. 🎉
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