Research group @karolinskainst, studying mucosal immunology with a focus on macrophages and innate lymphoid cells (ILCs), and immune cell migration
Joined October 2019
- Tweets 167
- Following 284
- Followers 981
- Likes 38
76 Photos and videos
Celebrating our recent JEM paper and Laura's PhD with nice Italian food😀
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Congrats, Laura, and all the best for your (bright) future!
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Very happy to see my PhD student Laura Bub defend her thesis yesterday 😀 Great discussion with opponent Sylvia Knapp from Vienna.
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Interested in immunometabolism of macrophages and metabolic crosstalk in the lung?
Read my review just published in @MucosalImmunol:
doi.org/10.1016/j.mucimm.202…
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Great collaboration with the labs of @bart_lambrecht and @gigaipl
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Congratulations to PhD student @laura_bub_ and other members of my lab who contributed to the study.
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(3) Our study provides a mechanism of how the loss of tissue-resident macrophages is sensed and establishes the new concept that metabolic cues from the tissue microenvironment instruct the differentiation of recruited monocytes into lung macrophages.
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(2) We found that fibroblasts produce 7alpha,25-dihydroxycholesterol in response to resident macrophage depletion, which recruits monocytes via the oxysterol receptor GPR183 to replenish macrophage niches in the lung.
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(1) We used single-cell RNA-sequencing and new macrophage depletion models to identify niche-derived signals that promote monocyte-derived macrophages.
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We discovered that cholesterol metabolites (oxysterols) recognized by the receptor GPR183 attract monocytes to repopulate depleted lung macrophage niches.
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Tim Willinger lab retweeted
11 Dec 2025
Online now: Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages dlvr.it/TPmLPM
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Tim Willinger lab retweeted
Feb 26
Online now: MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species dlvr.it/TRB67C
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20 Sep 2025
It was fun to reconnect with old friends and colleagues at Yale 😀😎
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20 Sep 2025
It was great to present our latest work on lung macrophages at the Richard Flavell Symposium.
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Tim Willinger lab retweeted
28 Jan 2025
Registration for #EMIG2025, the European Mucosal Immunology Group meeting in Aachen, Germany is now open. Save your spot today: emig2025.de
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1 Nov 2024
Very proud see former PhD student @elzaevren at the Conferment Ceremony @karolinskainst
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29 Oct 2024
Lots of interesting scientific discussions with engaged students 😀
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