As joint First Author, our recent publication @NatureBJC @BrJCancer. HDAC5's regulation of SATB1 impacts epigenetic remodeling of TSGs, underscoring their crucial connection in driving a malignant phenotype. nature.com/articles/s41416-0…

An example from evolutionary biology that Big and powerful don’t always win-adaptable does. And history keeps repeating in different ways. #reasons for species extinction.

Proud! 🇮🇳# Homi bhaba#Unlimited energy👏.

Well deserved Nobel Peace Prize 🥳Congratulations Maria.

Again to the field of immunology. 2025- Nobel! Congratulations to all the laureates😊🥳🥳

In the age of love and wedding flair, I'm pairing up mice—what an odd affair. While lovebirds court with charm and spice, I'm busy matchmaking lab-grown mice No dates, no rings, no wedding rice— Just edited genomes in lab-born mice. #Researchtales 😌

Our publication @ScienceAdvances reveals the mechanism behined the PARP1 dual function and why Olaparib monotherapy is enffective due to an active transcriptional axis. Combined inhibition of both axis cause an effective reduction of tumor growth. science.org/doi/10.1126/scia…

This was as expected...The era of machine learning. Congratulations to physics laureate 🎉.

The 45th FIDE #ChessOlympiad is in the books! Congratulations to the winners! 👏👏 🥇 India 🇮🇳 🥈 United States of America 🇺🇸 🥉 Uzbekistan 🇺🇿

Beautiful work discovering neuronal regulation of #ependymoma through histone serotonylation by the Twitter-less Ben Deneen! #CancerNeuroscience nature.com/articles/s41586-0…

NGS Vs Western blot😝.

Happy to contribute to the opportunity in immunology field provided by my PhD guide. CD40 agonist engineered immunosomes modulated tumor microenvironment a... sciencedirect.com/science/ar…

A supermassive black hole in galaxy SDSS1335 0728 has lit up, possibly giving astronomers a look at how such beasts are awakened. sciencenews.org/article/supe…

A hand warmer generally contains a supersaturated solution of sodium acetate which releases heat upon crystallization when a nucleation center is formed by pressing on the metal disc.

CODA day! The CODA team at @JohnsHopkins maps pancreatic precursor lesions in 3D and at single-cell level. First 3D spatial genomic maps of large tissue samples. A human pancreas contains a staggering ~1000 lesions, some showing multifocality. Here: nature.com/articles/s41586-0…

Immune checkpoint inhibitors, like anti-PD-1 and anti-CTLA-4, are effective against cancer, but not all patients respond How could the response be improved? Here's an idea from this week's issue of Science Giampazolias et al. found that feeding mice a diet high in vitamin D enriched the microbiome with a specific bacterium, Bacteroides fragilis If these vitamin D-enriched microbiomes were transplanted into new mice (via a fecal transplant, FT), they enhanced the activity of anti-CTLA-4 or anti-PD-1 therapy against tumours: In humans, high levels of genes controlled by vitamin D and its receptor (VDR) correlated with better response to checkpoint inhibition (CPI) by anti-PD-1 and anti-CTLA-4: What this suggests is that supplementing with vitamin D, a vitamin D-enriched microbiome, or Bacteroides fragilis itself, could enhance the antitumour immunity of checkpoint inhibitors - although this (to my knowledge) is yet to be directly tested in humans One question that arises: if the activity of anti-PD-1/anti-CTLA-4 against the tumour is increased, are there also more immune-mediated adverse events (e.g., inflammatory or autoimmune)? Here's the study: science.org/doi/10.1126/scie…

A thoughtful study from Zong et al. p53 lactylation from microenvironment suppresses it's activity promoting tumorigenisis. Amino acid (B-alanine) supplements from outside blocks this modification thereby increasing mouse survival. cell.com/cell/abstract/S0092…

First Summer'24 cooling Mango drink#all it takes to be happy#Love Mangoes🥰.

Excited to back PREVALL, India's 1st oral chemo for pediatric leukemia, by ICMR-CARE @ACTREC_TMC, in collab with @idrslabs. At about 1% cost of current available liquid formulations in US (Rs 1500 vs. Rs 1,27,000), it's a game-changer!

Nice! cell.com/cell/fulltext/S0092…

Before Tesla# 1912 Baker.