One of the most-viewed PNAS articles in the last week is “Enhanced visualization of influenza A virus entry into living cells using virus-view atomic force microscopy.” Explore the article here: ow.ly/UiEG50XHyci
For more trending articles, visit ow.ly/e8nb50XHycg.
ALT Establishment of virus-view AFM for IAV cell entry studies in MDCK cells.
Our ViViD-AFM paper is out in PNAS!
pnas.org/doi/10.1073/pnas.25…
Enhanced visualization of influenza A virus entry into living cells using virus-view atomic force microscopy
ALT ViViD-AFM is a hybrid live imaging technology that captures cell surface nanometric morphological features and fluorescent signals. It uses atomic force microscopy (AFM) specifically tailored for soft surface biological imaging. It is delicate enough to preserves weak virus-host interactions at the live cell surface. The image - showing an influenza A virus taken up into the cell by clathrin-mediated endocytosis - was created by @ScienceBrush Design.
Yamauchi @YamauchiLab presenting his #SARS -CoV-2 co-receptor study which was EU project of the month in Autumn 2020 and his more recent research on virus-inspired protein cages for cellular uptake to facilitate payload delivery in cells.
And here we go - this is how the entry of the influenza virus looks like. But the virus has even more stunning tricks - it uses, for instance, the host cell's waste disposal system to break down its capsid as Yamauchi @YamauchiLab explains.
Now we are off to a new universe - the universe of viruses. Yohei Yamauchi @YamauchiLab giving his inaugural lecture on “Decoding Virus Entry” enlightening the cell biology of virus entry.
This works comes from a fantastic collaboration with @YamauchiLab at @ETH_DCHAB and Patrick Matthias at @FMIscience on understanding the role of branched Ub chains in viral infections. For this we need homogenous Ub chains to reconstitute the machinery that uncoats viral capsids.
I was lucky to guest edit a Special Feature: Virus Microscopy for the journal Microscopy. Review by S. Padilla-Parra (HIV-1 transmission); T. Noda (filovirus structure); @Chr_Sieben orthohantavirus imaging); U. Greber (label-free microscopy). See issue 👉
academic.oup.com/jmicro/issu…
Life beyond the Pixels was a fantastic talk given by computational biologist Peter Horvath @hpke1980 @BiochemBrc for the IPW seminar series hosted by Yohei Y. #AI#singlecell#MolecularMedicineLab@ETH_DCHAB Thanks Peter for your visit to ETH!!
I highly recommend taking a look at "Catching the (viral) burglar", an engaging interview article written by Julia Ecker that effectively summarizes our research. chab.ethz.ch/en/news-and-eve…@ETH_DCHAB
Over the last several months the Molecular Medicine laboratory recruited PhD students Jiaxuan Fan @fjx0326 Cressida Harvey @cressidaharvey Amit Santhu @AmitSanthu and Master student Jannes Brender. Welcome aboard!! 👏@ETH_DCHAB@LifeScienceZH