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Yeates Lab @Yeates_Lab

Lab twitter account for the Todd Yeates group @UCLA

Joined September 2022
  • Tweets 5
  • Following 13
  • Followers 204
2 Photos and videos
Yeates Lab@Yeates_Lab
21 Mar 2024
Our new paper that uses machine learning to generate a suite of novel protein cages has just been published: cell.com/structure/fulltext/…

A suite of designed protein cages using machine learning and protein fragment-based protocols

Using machine learning and knowledge-based algorithms, Meador et al. design 24-subunit protein complexes in the shapes of tetrahedral nanoparticles or cages. Structural and biochemical methods...

cell.com
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Yeates Lab@Yeates_Lab
21 Mar 2024
Our creation of 'ligand-operable cages' -- designed protein cages that disassemble when they bind a specific cellular protein -- has been published: pubs.acs.org/doi/10.1021/acs…

Design of Ligand-Operable Protein-Cages That Open Upon Specific Protein Binding

Protein nanocages have diverse applications in medicine and biotechnology, including molecular delivery. However, although numerous studies have demonstrated the ability of protein nanocages to...

pubs.acs.org
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Yeates Lab@Yeates_Lab
28 Sep 2023
Our latest work on solving the cryo-EM problem for small therapeutic proteins is finally out. pnas.org/doi/10.1073/pnas.23… Congrats to Roger and the lab!

Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a...

Cryoelectron microscopy (Cryo-EM) has enabled structural determination of proteins larger than about 50 kDa, including many intractable by any othe...

pnas.org
Roger Castells@rcastellsg
9 Sep 2023
I'm thrilled to share our latest work on designing imaging scaffolds to determine the structure of small proteins using cryo-EM! pnas.org/doi/full/10.1073/pn…
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Yeates Lab@Yeates_Lab
19 Sep 2022
‘Rigidified Scaffolds for 3-Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets’ Congrats @rcastellsg @kylemeador and team! With our imaging scaffolds, we report a 2.9A structure for a ~19 kDa KRAS protein oncogenic mutant. biorxiv.org/content/10.1101/…
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Yeates Lab@Yeates_Lab
15 Sep 2022
Designing Protease-Triggered Protein Cages #proteincages #proteases #proteindesign pubs.acs.org/doi/abs/10.1021…
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