IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases go.nature.com/3vh5Bdv

Interested in working on the next generation of cancer immunotherapies? The Tang Lab at the Swiss Federal Institute of Technology in Lausanne is looking for a postdoctoral researcher with a strong background in immunology, metabolism, and mouse studies. See below for more info ⬇️

Thanks Pr. Richard Klemke for highlighting our work in Faculty Opinions. "Metabolic reprogramming of terminally exhausted CD8 T cells by IL-10 enhances anti-tumor immunity"- recommended in @FacultyOpinions facultyopinions.com/prime/74…

Thank ACIR for nice report for our work. acir.org/weekly-digests/2021…

Our lab's new paper (rdcu.be/clkR2) on metabolic reprogramming of exhausted CD8 T cells is now out at @natureimmunology, highlighted as a cover story! (1/7)

#cancer Tang and colleagues show that a half-life-extended IL-10–Fc fusion protein enhances proliferation and effector function of terminally exhausted T cells via metabolic reprogramming which can eradicate established solid tumors in mice.rdcu.be/cld9s