Stoked to present our latest, brilliantly led by Chris et al & Alejandro Torres-Sanchez. How tissues are patterned during development – we found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n biorxiv.org/content/10.1101/…
The heart is a remarkable organ, where form and function arise in parallel – in this case, the heart wall remodels to form a complex architecture, while the heart beats to support blood flow to the peripheral organs 2/n
Thrilled to see our latest work online @Dev_Cell! 🥳
How do cells build functional organs with precision?🫀🫁📏 Here, we show how coupling of cell shape and organ function tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
Out now! Our very first paper from the lab, an impressive feat by @tobyandrews
where we show how a developing heart grows and scales up its morphological complexity to keep beating...an excellent summary below ⬇️ cell.com/developmenta...
Thrilled to see our latest work online @Dev_Cell! 🥳
How do cells build functional organs with precision?🫀🫁📏 Here, we show how coupling of cell shape and organ function tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
Paper accepted 🥳Many congratulations @tobyandrews! So proud of what you have achieved! Can’t wait to see what you do next... Onwards and upwards from here!
This was a fun exercise... reflecting on my accidental path into science, the questions that drive our lab @TheCrick and thoughts on building a more inclusive scientific community. Grateful for the opportunity
@focalplane_jcs and Subhajit .
‘These cracks, they let the developing cells in: A chronicle of trabeculation in the developing zebrafish heart’ 🎵
Theodora Stougiannou highlights recent work from @_Priya_R & team. #preprint
Check out the #preLight ⬇️ 👀
prelights.biologists.com/hig…
...and If this piqued your interest, we have fully-funded postdoc positions (4 2 years) available! Join the dynamic, collaborative community @TheCrick with access to top-tier technology platforms and an outstanding postdoc training program. Please RT 🙏
crick.wd3.myworkdayjobs.com/…
Stoked to present our latest, brilliantly led by Chris et al & Alejandro Torres-Sanchez. How tissues are patterned during development – we found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n biorxiv.org/content/10.1101/…
Stoked to present our latest, brilliantly led by Chris et al & Alejandro Torres-Sanchez. How tissues are patterned during development – we found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n biorxiv.org/content/10.1101/…
importantly fractures/cracks/defects are not always destructive - biological materials can self-fracture to generate shapes, see Santos-Durán 2025; Dumortier 2019; Duque 2024; Prakash 2021, others ...‘Break To Build’ 🛠️ (stay tuned for more 😎) #BioPhysics#Mechanics 11/n
A true team effort brilliantly led by Chris in collaboration with Alejandro, Emily, MC, Toby et al & many others
@TheCrick and friends for discussions/feedback. #zebrafish#HeartMorphogenesis#DevBio Do let us know your feedback/questions 🙏 12/12