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Human BioMolecular Atlas Program (HuBMAP) @_hubmap

an NIH-funded consortium of scientists developing an open, global framework for comprehensively mapping the human body at a cellular resolution.

Joined March 2019
  • Tweets 1,022
  • Following 124
  • Followers 2,061
237 Photos and videos
Human BioMolecular Atlas Program (HuBMAP) retweeted
NIH
@NIH
Jun 11
NEWS: NIH research establishes new framework for the role of senescence in aging. Read the full story ➡️ nih.gov/news-events/news-rel…
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Once again, the certified #_HuBMAP air-tists/researchers in Dr. Gloria Pryhuber's lab at @UR_Med hope to take your breath away with this multimodal image of airway epithelium, submucosal gland, and duct from the lung. We hope it respires you to live lung and prosper.
Multimodal image of airway epithelium, submucosal gland, and duct from the lung. Lung - Airway Epithelium and Submucosal Gland and Duct PTPRC - CD45 - Orange - immune cells PECAM1 - CD31 - Green - endothelial cells KRT5 - Yellow - basal epithelial cells ACTA2 - White - smooth muscle cells FOXJ1 - orange in epithelium, motile ciliated cells SCGB3A2 - pink - lung epithelial cells and submucosal glands SFTPB - pulmonary surfactant protein MUC5AC - bright blue - gel-forming glycoprotein in the lungs MUC5B - turquoise - gel-forming mucin protein

ALT Multimodal image of airway epithelium, submucosal gland, and duct from the lung. Lung - Airway Epithelium and Submucosal Gland and Duct PTPRC - CD45 - Orange - immune cells PECAM1 - CD31 - Green - endothelial cells KRT5 - Yellow - basal epithelial cells ACTA2 - White - smooth muscle cells FOXJ1 - orange in epithelium, motile ciliated cells SCGB3A2 - pink - lung epithelial cells and submucosal glands SFTPB - pulmonary surfactant protein MUC5AC - bright blue - gel-forming glycoprotein in the lungs MUC5B - turquoise - gel-forming mucin protein

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Lung - Airway Epithelium and Submucosal Gland and Duct PTPRC - CD45 - Orange - immune cells PECAM1 - CD31 - Green - endothelial cells KRT5 - Yellow - basal epithelial cells ACTA2 - White - smooth muscle cells
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FOXJ1 - orange in epithelium, motile ciliated cells SCGB3A2 - pink - lung epithelial cells and submucosal glands SFTPB - pulmonary surfactant protein MUC5AC - bright blue - gel-forming glycoprotein in the lungs MUC5B - turquoise - gel-forming mucin protein
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Does this CODEX image of an ovary send you ova the moon? This egg-citing image was made by NIH funded #_HuBMAP scientists @UPenn & @LurieChildren's, using antibodies specific to cell types found in the ovary to show the spatial relationships within. Ova it? Never!!!!
CODEX image of an ovary follicles - red and blue, luteinizing cells - pink, extracellular matrix - purple, green, white, vessels - yellow and orange

ALT CODEX image of an ovary follicles - red and blue, luteinizing cells - pink, extracellular matrix - purple, green, white, vessels - yellow and orange

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follicles - red and blue, luteinizing cells - pink, extracellular matrix - purple, green, white, vessels - yellow and orange
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Not to be an ovary-achiever, but this CODEX image of oocytes in a healthy human ovary made by scientists at @UPenn & @LurieChildren’s is egg-straordinary! Images like this prove researchers aren’t just follicle-ing around! 😉
CODEX image of oocytes in a healthy human ovary. Green – oocytes, Pink – extracellular matrix, Cyan – vessels, Blue and Yellow – epithelial cells Photo credit - UPenn & Lurie Children’s (O’Neill, Kim, Laronda)

ALT CODEX image of oocytes in a healthy human ovary. Green – oocytes, Pink – extracellular matrix, Cyan – vessels, Blue and Yellow – epithelial cells Photo credit - UPenn & Lurie Children’s (O’Neill, Kim, Laronda)

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Photo credit - UPenn & Lurie Children’s (O’Neill, Kim, Laronda)
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Green – oocytes, Pink – extracellular matrix, Cyan – vessels, Blue and Yellow – epithelial cells
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Do you have the intestinal fortitude to check out your viscera? Then follow your gut instincts and digest this CODEX image of a healthy colon from John Hickey when he was at the of the Nolan Lab Stanford. We hope it bowels you over as much as us!
CODEX image of a healthy colon

ALT CODEX image of a healthy colon
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Pi day just passed, so you know what that means! It's time for a slice of kidney pi(e), and that's a renal treat! This CODEX image of a kidney pi slice was made by #hubmap researchers Drs. Tarek Ashkar & Sanjay Jain @wustl, and we're not being irrational!
CODEX image of a kidney pi slice Red - podocytes, green - endothelial cells, yellow - smooth muscle cels and arterioles, cyan - thick ascending limb tubules, blue - proximal tubules, brown - distal convoluted tubules

ALT CODEX image of a kidney pi slice Red - podocytes, green - endothelial cells, yellow - smooth muscle cels and arterioles, cyan - thick ascending limb tubules, blue - proximal tubules, brown - distal convoluted tubules

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Red - podocytes, green - endothelial cells, yellow - smooth muscle cels and arterioles, cyan - thick ascending limb tubules, blue - proximal tubules, brown - distal convoluted tubules
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Not to be ovary-serious, but this CODEX image of an ovary made by HuBMAP researchers Elizabeth Tsui, Hannah McDowell (Laronda lab at @NUFeinbergMed) & Alex Cabrera, Jean Rosario (O'Neill lab @PennMedicine) is egg-squiste! Hopefully, it fertilizes and catalyzesyour imagination!
CODEX image of an ovary. Stroma and ECM - green and blue; Endothelium - red, white, magenta, and cyan; Macrophages - yellow

ALT CODEX image of an ovary. Stroma and ECM - green and blue; Endothelium - red, white, magenta, and cyan; Macrophages - yellow

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Stroma and ECM - green and blue; Endothelium - red, white, magenta, and cyan; Macrophages - yellow
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DYK that bone marrow makes your blood cells? To get to the meat of the matter, come see this MIBI-TOF image visualized in CellTune, a software that classified the cells across the tissue section. Not to be too bloody marrow-minded, but this CellTune software sings! 😊
MIBI-TOF image visualized in CellTune, a software that classified the cells across the tissue section Yellow – lipid droplets, green – natural killer cells, light blue – endothelial cells, magenta – smooth muscle cells, orange – erythroid cell precursors, white – type I collagen, dark blue – hematopoietic stem cells

ALT MIBI-TOF image visualized in CellTune, a software that classified the cells across the tissue section Yellow – lipid droplets, green – natural killer cells, light blue – endothelial cells, magenta – smooth muscle cells, orange – erythroid cell precursors, white – type I collagen, dark blue – hematopoietic stem cells

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biorxiv.org/content/10.1101/…
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Yellow – lipid droplets, green – natural killer cells, light blue – endothelial cells, magenta – smooth muscle cells, orange – erythroid cell precursors, white – type I collagen, dark blue – hematopoietic stem cells
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Decided to see this mass spec image of the decidua from MikeAngeloLab @stanford? Excellent choice! The decidua lines the uterus during pregnancy & forms the placenta. This image also captures fetal cells within & around maternal spiral arteries because we always deliver for you!
Image of the decidua, also captures fetal cells within and around maternal spiral arteries.

ALT Image of the decidua, also captures fetal cells within and around maternal spiral arteries.
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To beat or not to beat that is the question Whether 'tis nobler in the mind to skip a beat Or pulsate with joy over the heartistry Of an image made by @GEHealthCare Using CellDIVE to see inner workings Of the heart is work not done in vein Tis a consummation devoutly to be wish'd
CellDIVE Image of the Heart Nuclei - blue, Immune cells - green, basement membrane - red, cardiomyocyte membranes - yellow, smooth muscle cells - cyan, endothelial cells - magenta

ALT CellDIVE Image of the Heart Nuclei - blue, Immune cells - green, basement membrane - red, cardiomyocyte membranes - yellow, smooth muscle cells - cyan, endothelial cells - magenta

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Nuclei - blue, Immune cells - green, basement membrane - red, cardiomyocyte membranes - yellow, smooth muscle cells - cyan, endothelial cells - magenta
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