💜 Inscripción abierta
Diplomatura en Enfermedad Cardiovascular en la Mujer (2° cohorte)
📅 Abril 2026
👩⚕️ Dirigido a profesionales de la salud
Formación actualizada y basada en evidencia.
📩 diploenfcardiovascularenlamujer@unvm.edu.ar
#SIAC#Cardiología#CardioMujer
🧠 Key insight in cardiac amyloidosis imaging
Visual score (Perugini) is NOT the same between planar and SPECT.
➡️ Weak agreement (κ ≈ 0.51)
➡️ Planar imaging → higher false positives
➡️ SPECT = diagnostic standard
🚨 Only SPECT visual score should guide ATTR. @JNCjournal
👉 PCSK9 & Alzheimer’s disease — lipids meet neurodegeneration
PCSK9 is moving beyond lipidology into the neurodegeneration arena.
👆 Mechanistic rationale is strong:
Degradation of neuronal LDLR, LRP1, ApoER2 → disrupted brain cholesterol handling.
👆 Downstream experimental effects:
↑ Amyloid-β accumulation
↑ Tau phosphorylation
↑ Neuroinflammation
↓ Synaptic integrity
👆 Overexpression accelerates amyloid pathology and cognitive decline (preclinical).
👆 Inhibition or genetic deletion mitigates these pathways and preserves cognition in models.
Human evidence tells a different story
👆 Some cohorts show higher PCSK9 levels in CSF and brain tissue.
👆 But large genetic and Mendelian randomization analyses:
No causal association with Alzheimer’s risk.
📍 PCSK9 inhibitors
• Powerful LDL-C reduction.
• No cognitive harm signal in trials.
• Limited blood–brain barrier penetration → effects likely indirect.
📍 Take-home
• Strong biology.
• Weak human causality.
• PCSK9 sits at the crossroads of lipid metabolism and neurodegeneration — best viewed today as a disease modifier or biomarker, not a driver.
🔗 Open Access 10.3390/life15121851
@society_eas
#cvImaging is undergoing a major transformation & this month's #CardiologyMag cover story explores the 🆕 multisociety Advanced Training Statement on Advanced Cardiovascular Imaging & its role in shaping future training pathways for evolving CV care. More: bit.ly/49DECe1
Si asistes al Congreso #SAC25 te esperamos en nuestro stand (núm 44)
Podrás adquirir nuestros libros
- Libro Azul
- Clínicas Interamericanas
- Cardiologia Crítica
Te esperamos!!!!
@SAC_54
Durante el Congreso #SIACprevent2025 se presentó un nuevo libro SIAC:
“Ateroesclerosis sublínicas: el valor de un diagnóstico temprano”
Editores: Dres. Adriana Puente, Vladimir Ullauri, Mildren del Sueldo, Yoloxochitl García Jiménez, Alberto Lorenzatti y Carlos Ponte
@acepuba@vladullauri1@Mdelsueldo@JYologarcia@ALorenzatti@DrPontecarlosi
FELICITACIONES!!!
Durante el Congreso #SIACprevent2025 se presentó un nuevo libro SIAC:
“Ateroesclerosis sublínicas: el valor de un diagnóstico temprano”
Editores: Dres. Adriana Puente, Vladimir Ullauri, Mildren del Sueldo, Yoloxochitl García Jiménez, Alberto Lorenzatti y Carlos Ponte
@acepuba@vladullauri1@Mdelsueldo@JYologarcia@ALorenzatti@DrPontecarlosi
FELICITACIONES!!!
Terminando una gran experiencia en Congreso ESC 2025 Madrid. Siempre una oportunidad para actualizar conocimientos y saludar a los amigos ! No vemos Múnich 2026.
👉Primary Prevention Aspirin,
Lipoprotein(a), and Cardiorenal
Outcomes in Chronic Kidney Disease
New data from the CRIC study
☝️In CKD patients without clinical CVD, aspirin use was associated with 38% lower MI risk and 28% lower ESRD risk — but only when Lp(a) ≥50 mg/dL.
☝️No significant benefit was seen when Lp(a) <50 mg/dL, and bleeding risk did not increase.
@society_eas@Lpa_Doc@rblument1@MichaelJBlaha@JACCJournals
Open access 🔓
sciencedirect.com/science/ar…
Attenuation artifacts (AC): validated protocols employ sequential scans performed in two different positions such as supine/upright or supine/prone imaging because changes in soft tissue positioning help to detect AC. @JNCjournal@MyASNC@acepuba@alexsfelixecho@estelais#CVNuc