What happens when you suddenly remove half of an essential enzyme from cells? 🤔
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
Pretty happy to share this work on RNA polymerase II!
We had a lot of fun studying this seemingly quite fundamental component of the system controlling Pol II levels & transcription. Amazing to get to work closely with Ana's group on this, combining imaging with genomics.
📢 New paper from the lab!
In a fantastic new collaboration with @ana_tufegdzic lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta @caciopporobi, Alex @acftbl, Ivan @IvanShlamovitz, and Andrew.
cell.com/molecular-cell/full…
fascinating and ambitious work. @tobinatthelab Do you have any further data on the apparent selectivity over M2/3? It would be good to see HTL9936 tested in an additional assay to pERK, tested for antagonism, or some competition affinity measurements.
Reminder to join your union wherever ever you work. There’s a lot that is crook about modern unis but pressure from organised labour protects workers. I am one (hopefully of many) beneficiary of this campaign against historical underpayment.
NTEU members knew USyd had a chronic underpayments issue. Without the activism of NTEU members, USyd would have been able to sweep this under the rug. Now workers will be paid what they're owed. nteu.org.au/join to help your fellow members stop wage theft! #highered
This is only becoming more important as more of us are pushed into casual or precarious employment. Big companies like USYD will exploit you if you let them.
With the publication of this interesting paper (and our associated commentary), I thought I would go through some elements of the broader discussion to highlight some work we were unable to cite.
nature.com/articles/s41386-0…
As we discuss in our commentary, there is clearly a complex and yet to be understood series of mechanisms leading to both opioid tolerance and somatic withdrawal.
doi.org/10.1038/s41386-021-0…
The precise role of MOR phosphorylation, and βarrestin recruitment, in this is an interesting outstanding question. More critically, it is unclear to what extent tolerance and withdrawal signs relate to 'addictive liability' of certain ligands.
“When I asked him how I should write about his life, he pulled out of his desk a list of every graduate student, postdoc and visitor at his laboratory”
We should all look up to someone who saw the politics in science and the science in politics.
nature.com/articles/d41586-0…
Racism and other preconceived prejudices have always and continue to influence biology. Disingenuous interpretations of biology continue to be used in many horrible ways.