Hypersensitivity reactions: the framework boards test constantly
Type I (Immediate/IgE): anaphylaxis, asthma, allergic rhinitis
β Mast cells IgE allergen β histamine release
Type II (Antibody-mediated): hemolytic transfusion rxn, Graves', myasthenia gravis, Goodpasture
β IgG/IgM attack cell surface antigens
Type III (Immune complex): serum sickness, SLE, post-strep GN, polyarteritis nodosa
β Ag-Ab complexes deposit in vessels β complement activation β inflammation
Type IV (Delayed/T-cell): TB skin test (PPD), contact dermatitis, MS, Type 1 DM
β Sensitized T cells β cytokines β NO antibodies
Key: Type IV = only one with NO antibody involvement.
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