I’m an AI researcher turned brain tumor patient, and recently I used the models to crack my mystery fatigue faster than my PCP could. I believe everyone can do the same with their own symptoms. Here’s how:

1/ I’m excited to share that I’ll be taking on an additional role as Head of Research for Thrive Holdings, alongside my work at OpenAI.

in markets, to go long on something is to bet it grows more valuable over time. much of the conversation today is short on humans, wagering that ai makes people redundant. we believe the opposite is true for the industries @ThriveHoldings operates in. we are long humans. thriveholdings.com/long-huma…

At @ThriveHoldings, we built a product with @OpenAI to automate tax prep for the 30 accounting firms we own across the country. This season, it processed 7k returns. But what I think is more interesting is that the product meaningfully self-improved as accountants used it.

New preprint with @J_Pablo_Bonilla! We built a neural network that decodes quantum errors — and discovered that fault-tolerant quantum computing might need far fewer qubits than we thought. 📄 Paper: arxiv.org/abs/2604.08358 Website: andigu.github.io/projects/ca…

1/ I’m excited to share recent work on a scalable and generalizable causal discovery framework from @mingZedh, me and @sophokevl, supervised by @elhamazizi. Open the thread 🧵 for a brief tweetorial of our method. arXiv link: arxiv.org/abs/2603.03411v1.

Reliving my recent japan trip through MinecraftLM (github.com/mattzh72/minecraf…), our world building agent. Some examples in 🧵 Prompt: "A traditional Japanese onsen as an isometric diorama. A small wooden bathhouse building with tiled roof, noren curtains at the entrance, and shoe lockers visible inside. Behind it, an outdoor hot spring pool surrounded by natural rocks, steam rising from the water. Wooden deck connecting the bathhouse to the pool with a small changing area, towel racks, and wooden buckets. Bamboo fence enclosing the space, stone lanterns along a path, maple trees with red leaves overhead. Snow on the ground and rocks for the classic winter onsen look. The bathhouse glows warm from inside, contrasting with the cold outside."

holiday feature: selectors to easily preview mobile, tablet and desktop views @withcascade

excited to share our explorations with gemini 3 flash check out our repo in the thread!

1/ All the structures you see here were generated by an LLM from a single text prompt (notably, Gemini-3 👀). Over the past week, we’ve been researching the spatial understanding capabilities of agents and how they can build large scale, playable environments (particularly Minecraft to start). We found they do extremely well despite what many think. We're open-sourcing our work for others to build on top of github.com/mattzh72/minecraf…

branch to explore → merge → repeat light mode vs. dark mode explored @withcascade