@blehall profile picture
Benoit Lehallier @blehall

#Nonlinearthinker #Omicsaholic

Joined January 2012
  • Tweets 114
  • Following 239
  • Followers 325
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I’m excited to present Chronos at @KeystoneSymp Closing the #DiversityGap in Global #Genomics, Medicine and #PopulationHealth, kicking off today in Hannover! I’d love to connect - feel free to DM me to set up a 1:1 conversation. keysym.us/KSPopulationHealth… #KSPopulationHealth26
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What if we could detect Parkinson's disease up more than a decade before symptoms appear? We just published results from Chronos-PD, leveraging a unique resource: 100 million archived plasma samples from routine donations. Here's what we found 🧵 medrxiv.org/content/10.64898…

Early Parkinson’s Revealed by Unlocking Longitudinal Omics at Population Scale

Many diseases begin developing years before symptoms appear[1][1]–[3][2], yet biospecimens from these early stages are rarely available. We developed Chronos, a framework that uses privacy-preserving...

medrxiv.org
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This work was funded by MJFF and built on Alkahest/Grifols' unique sample repository. Massive team effort - full author list and data access info coming with preprint. The data will be made fully available to the research community. Early access possible 🔓
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#Parkinsons #Proteomics #EarlyDetection #Biomarkers #Neurodegeneration #PrecisionMedicine
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Large-scale proteomics is unlocking in a new era of biomarker discovery and therapeutic target identification. #Chronos offers a unique opportunity: high-temporal-resolution profiling of 100 millions longitudinal plasma samples across pre-clinical phases of any disease (1/5)
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💡 The team is making rapid progress, and groundbreaking results are just around the corner—stay tuned for updates! Honored to be the #PI of this transformative program (4/5)
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Learn more about this pioneering initiative and MJFF's impactful grant funding here: 👉 Chronos-PD Grant Details michaeljfox.org/grant/chrono… (5/5)

Chronos-PD: Using Proteomic Analysis to Detect Early Molecular Signatures of Parkinson’s Disease

Study Rationale: Parkinson’s disease (PD) is a gradually progressive condition: by the time the disorder is recognized and diagnosed, it is often too late to protect or reverse the damage that has...

michaeljfox.org
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Benoit Lehallier retweeted
Oliver Hahn
@Oliver__Hahn
21 Sep 2022
Excited to share our preprint about the spatiotemporal dynamics of mammalian #brain aging. With our new map generated at @wysscoray lab, we made a step towards understanding when and how the 🧠 ages! 1/9 biorxiv.org/content/10.1101/…

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

Aging is the key risk factor for loss of cognitive function and neurodegeneration but our knowledge of molecular dynamics across the aging brain is very limited. Here we perform spatiotemporal...

biorxiv.org
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Preprint alert! A must read from Oliver Hahn who generated a spatiotemporal gene expression map of 15 brain regions! This study shows that the white matter tracts are an early hotspot of brain aging! Many other cool findings to discover here 👇 biorxiv.org/content/10.1101/…

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

Aging is the key risk factor for loss of cognitive function and neurodegeneration but our knowledge of molecular dynamics across the aging brain is very limited. Here we perform spatiotemporal...

biorxiv.org
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Data from NIH-funded studies will have to be shared. This won't be straightforward to implement but that's a huge step for open science 👇
Florian Krammer
@florian_krammer
23 Jan 2022
1) On January 25th 2023 a new data sharing policy from NIH kicks in which basically requires raw data from NIH-funded studies to be shared. Data is defined as:
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