Joined July 2019
16 Photos and videos
Pinned Tweet
Perspective outlining multiple entry points for studying the molecular basis of human brain evolution with @TylerFair_ sciencedirect.com/science/ar…
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Alex Pollen retweeted
Interested in single cell genomics but need help getting started? Come to my lab's 10th (!) Single Cell Genomics Day on 6/12 Talks include Aviv Regev @anshulkundaje @junyue_cao @xinjin (many) more @ATJCagan illustrations! Free Youtube livestream at satijalab.org/scgd

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Form follows function, or function dictates form? 📢Preprint: we build Perturb-CLEAR, in vivo screen of neuroanatomy! Disease perturbations produce selective morphology-RNA changes that RNA impact alone cannot predict. Was led by the invincible @BoliWu! biorxiv.org/content/10.64898…
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New preprint on Detectrons from @jihoon_han_phd! These are programmable biosensors for RNAs that produce DNA barcodes in the presence of their target RNA. Check out Jihoon's quoted thread for more: biorxiv.org/content/10.64898…
Excited to share a preprint from my postdoc work in @seth_shipman’s lab! We developed Detectrons — programmable biosensors that convert RNA signals into stable DNA barcodes inside living cells, enabling multiplexed RNA sensing. 🧵👇 biorxiv.org/content/10.64898…
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Alex Pollen retweeted
NEXT TUE: DDD seminar, Feb. 17, 2026 @ 1PM Eastern US: Dr. Annerieke Sierksma (Dr. Bart De Strooper's @BStrooper group @ KU Leuven) present "Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo". carlocolantuoni.org/seminar
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Alex Pollen retweeted
Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday. Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
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Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element biorxiv.org/content/10.64898…

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Alex Pollen retweeted
Excited to share work I contributed to during my UCSF postdoc with amazing colleagues, including Dr. Tianzhi Wu & Dr. Jingjing Li! @Kriegsteinlab @jingjingSF @UCSFstemcell ❤️ nature.com/articles/s41587-0…

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9/ We hope our study will provide a framework for functionally studying how disease and evolution shape human cortical development.
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Alex Pollen retweeted
New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.
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Alex Pollen retweeted
Congratulations, Tomasz Nowakowski! #UCSFProud
Congratulations to Tomasz Nowakowski, PhD, on being named a finalist for the prestigious Blavatnik National Award for Young Scientists! 🎉 He was selected for his groundbreaking research shaping the future of neuroscience and medicine. @BlavatnikAwards stemcell.ucsf.edu/news/tomas…
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