RCSB PDB promotes a structural view of biology. Funded by @NSF, @thenci, @NIAIDNews, @NIGMS, @NIH, & @doescience. Contact info@rcsb.org with service questions.
Joined October 2009
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rcsb.org/news/637ce5f266d604β¦
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How changes to proteins can alter drug interactions for new precision therapies
Scripps Research team maps how chemical modifications to proteins affect drug binding across the human proteome.
scripps.edu/news-and-events/β¦
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Download an image of GLP-1 receptor recognizing a GLP-1 analog, with liraglutide free in solution.
Open access to PDB structures facilitate discovery and development of new treatments for diabetes.
pdb101.rcsb.org/learn/flyersβ¦
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Scientists are actively researching ways to make phage therapies more effective. This includes efforts to engineer phages to expand their host range and aid in bacterial defense system evasion.
More at Molecule of the Month: pdb101.rcsb.org/motm/318
ALT Left: JBD30 is a siphophage that infects Pseudomonas aeruginosa by attaching to hair-like pili on the bacterial surface. This illustration was created by combining pdb_00008rkc, pdb_00008rkb, pdb_00008rk9, pdb_00008rk8, pdb_00008rk7, pdb_00008rk6,pdb_00008rk5, and pdb_00008rk4. Right: Andhra is a podophage that infects Staphylococcus epidermidis. This illustration was created by combining pdb_00008egt, pdb_00008egs, pdb_00008egr, and pdb_00008ej5.
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Clathrin triskelions will bind to other membrane-attached triskelia to form a rounded lattice of hexagons and pentagons, reminiscent of the panels on a soccer ball, that pulls the membrane into a bud.
pdb101.rcsb.org/motm/88
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rcsb pdb ππ§¬π»π¬ππ±π§ π¦ retweeted
1/ This month marks 5 years since the Glass Lab moved to @uvmvermont. A quick look at what the team built. π§΅π§¬
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Learn to Use Mol* for 3D Visualization
Videos and tutorials are available to help users become Mol* experts
rcsb.org/news/feature/68e80dβ¦
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Specific amino acid sequences give proteins their distinct shapes and chemical characteristics. Proteins rely on the recognition of specific 3D molecular shapes to function correctly for DEFENSE, TRANSPORT, ENZYMES, STRUCTURE, STORAGE, and COMMUNICATION
pdb101.rcsb.org/learn/videosβ¦
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Watch the Tutorial: Introduction to Molecular Animation
Learn how to use ChimeraX to create simple animations that can enrich your presentations, websites, and social media
pdb101.rcsb.org/train/trainiβ¦
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Building a better model for drug delivery across the bloodβbrain barrier
asbmb.org/asbmb-today/sciencβ¦
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A New Framework for Designing Synthetic Enzymes
This work, verified using X-ray techniques at the Advanced Light Source (ALS), offers a cost-effective, scalable approach that paves the way for functional materials in biomedicine, energy, and manufacturing
als.lbl.gov/a-new-framework-β¦
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Myoglobin Fold (1987) by Irving Geis
Used with permission from the Howard Hughes Medical Institute. All rights reserved.
Learn more about Irving Geis and his his iconic images of DNA, hemoglobin, and other important macromolecules at PDB-101
pdb101.rcsb.org/sci-art/geisβ¦
ALT Geis illustrated the structure of myoglobin, focusing on the folding pattern of the secondary structure of the protein. Unlike previous myoglobin Illustrations, this painting focuses on the tertiary structure of the molecule rather than the sequence or surface.
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Thanks to @DECTRIS_News (dectris.com), a wwPDB Foundation sponsor.
DECTRIS has developed and manufactured X-ray and electron cameras to spark scientific breakthroughs around the world for 20 years
Visit foundation.wwpdb.org sponsorship opportunities
ALT DECTRIS logo plus graphic celebrating 20 Years of Enabling Scientific Breakthroughs
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Exploring the Structural Biology of Bioenergy at PDB-101
Cells capture and utilize many forms of energy to power their molecular processes
pdb101.rcsb.org/learn/explorβ¦
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"The AlphaFold advance was possible only because of the Protein Data Bank, a laboriously created database of protein structures that the National Science Foundation began funding in the 1970s. No Protein Data Bank, no AlphaFold."
nytimes.com/2026/05/31/opiniβ¦
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Molecular Origami: Build 3D Paper Models of Protein Domains
Download printable alpha helices and beta strand templates for hands-on exploration of protein folding domains, including a TIM Barrel and a Beta Sandwich
pdb101.rcsb.org/learn/paper-β¦
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Computed Structure Models (CSMs) at RCSB PDB Updated from AlphaFold, ModelArchive
Updated CSMs include data from AlphaFold v6 and a refresh of files from the ModelArchive
rcsb.org/news/feature/6a0dcaβ¦
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Molecule of the Month: Therapeutic Phage
Using the natural predators of bacteria to fight antibiotic-resistant infections
pdb101.rcsb.org/motm/318
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Researchers pioneer method to rapidly design proteins
Their strategy revealed new details that open the door to designing proteins with powerful abilities that could ultimately benefit medicine and manufacturing.
slac.stanford.edu/news/2026-β¦
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A nanosized extract of the plant thylakoid grana β the molecular engine behind photosynthesis β is transplanted into the eyeβs corneal cells, producing a key protective molecule when exposed to ambient light, opening a new front against dry eye disease
news.nus.edu.sg/eyes-that-phβ¦
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