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Calico @calico

Calico is a research and development company tackling one of life's greatest mysteries, the biology that controls human aging.

Joined June 2016
  • Tweets 161
  • Following 40
  • Followers 8,118
108 Photos and videos
Calico’s Head of AI/ML, Matt Onsum, recently took part in the @Caltech Longevity Hackathon, where students, researchers, engineers, and founders came together to explore new approaches to aging and longevity science. (1/3)
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Throughout the weekend, teams developed technologies spanning biology, neuroscience, AI, and medicine. Matt spoke about how machine learning is advancing drug discovery at Calico and creating new opportunities for scientific progress. (2/3)
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We enjoyed the opportunity to connect with a community so deeply engaged in exploring how computation and biology can shape the future of aging research. (3/3)
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Calico@calico
May 27
We’re looking forward to joining the nephrology community at the 63rd ERA Congress in Glasgow, June 3–6.
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Calico@calico
May 27
Calico will be onsite to discuss our ongoing research in ADPKD, including our work studying PAPP-A, a modulator of insulin-like growth factor (IGF) signaling involved in disease biology.
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Calico@calico
May 27
We will also share details about our ongoing global Phase 2 clinical study currently enrolling adults with #ADPKD. If you’ll be attending #ERA26, stop by booth E.100 and join our Trial in Progress Presentation June 5 at 17:45 pm BST in Focused Oral Room 4. #KidneyResearch
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Calico@calico
Apr 14
A Sr. Scientist in the Hahn Lab, @Claire_gizowski studies how the brain’s resident immune cells, microglia, are influenced by their local environment, so we can better understand and support healthy brain aging. We asked why she chose to join Calico. calicolabs.com/life-at-calic…
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In Nature Comms: Our scientists & collaborators at the Popko Lab (Northwestern Univ.) & Chen Lab (Loyola Univ. Chicago) found that inhibiting the Integrated Stress Response extended lifespan in a mouse model of a rare childhood leukodystrophy, Pelizaeus-Merzbacher disease. (1/5)
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Changing its activity may help rebalance the stress response, a mechanism relevant not only to PMD but also to other rare white matter disorders. Read study: nature.com/articles/s41467-0… Learn about our work on the ISR & Vanishing White Matter disease: calicolabs.com/clinical-tria… (4/5)

Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse...

Nature Communications - Pelizaeus-Merzbacher disease (PMD) is due to myelin proteolipid protein gene mutations. Here, the authors show that inhibiting the integrated stress response extends the...

nature.com
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Image: Oligodendrocytes (shown in culture) are specialized brain cells that produce myelin, a fatty, insulating sheath that encases axons. They're the primary cell type implicated in PMD, where mutations in the proteolipid protein 1 (PLP1) lead to their dysfunction & death. (5/5)
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Calico@calico
Mar 24
As a Staff Software Engineer, Danny Park designs software and computing tools that make complex data more usable so our scientists can perform research more effectively and answer new questions about aging biology. We asked what brought him to Calico. calicolabs.com/life-at-calic…
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Calico@calico
Mar 19
Autosomal dominant polycystic kidney disease, or ADPKD, is the most common inherited form of kidney disease worldwide. (1/5)
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Calico@calico
Mar 19
During National Kidney Month, we’re sharing how our research continues to deepen the understanding of how ADPKD progresses and the biology behind it. We are translating these insights into a global Phase 2 clinical study in adults with ADPKD. (4/5)
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Calico@calico
Mar 19
Learn more in this video, and access trial information here: anchoradpkd.com #NationalKidneyMonth (5/5)
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Calico@calico
Mar 6
We wouldn’t be where we are without our team. We’re honored to work with some of the most dedicated, curious and creative colleagues who share our commitment to understand aging and improve healthspan. Here’s to another year of advancing science! #EmployeeAppreciationDay
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Calico@calico
Feb 25
Our 4th annual Hack Week brought together colleagues to think creatively and explore new ways of working with data. Prior Hack Week projects have helped inform new computational science direction for Calico, and we look forward to seeing where these new ideas lead!
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