“The promyelocytic leukemia PML protein coordinates immune evasion in triple-negative breast cancer via independent and converging mechanisms”
A new study from @BernardiLab uncovers a potential new target to boost immunotherapy ⤵️
nature.com/articles/s41418-0…
“Single cells and spatial RNA profiling reveal that inflammatory fibroblasts arise from Edil3 stromal cells in the colon after irradiation”
This study offers key insights into the colonic stroma composition ⤵️
nature.com/articles/s41418-0…
“A PML1-CCL5-PI3K/MAPK feedback loop governs survival of endocrine-resistant breast cancer cells”
This study by @HanWang23263640 and colleagues identifies PML1 as a key "resistance hub" ⤵️
nature.com/articles/s41418-0…
“Pancreatic cancer induces B cell lineage plasticity via Pax5 inhibition to sustain immunosuppression”
A fascinating immune evasion mechanism whereby PDAC reprograms B cells to acquire a myeloid immunosuppressive phenotype ⤵️
nature.com/articles/s41420-0…
“Cell death–induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation”
ACBP/DBI as a systemic biomarker of cell death and organ injury in humans and mice across multiple disease contexts and experimental models ⤵️
nature.com/articles/s41418-0…
“When vitamins decide life or death”
Explore the multilayered model of vitamin-dependent regulation of cell death in our latest Editorial by Daolin Tang, @melino_G, and Guido Kroemer ⤵️
nature.com/articles/s41418-0…
“EGFR deletion in myeloid cells reprograms the immunosuppressive landscape of colorectal cancer”
A groundbreaking multi-omics study from @CCR_SibiliaLab reveals EGFR in specific myeloid cell subsets as a potential new therapeutic target in mCRC ⤵️
nature.com/articles/s41418-0…
“Akt-mediated RALY phosphorylation functions as a molecular switch governing c-Myc stability”
Researchers uncovered the oncogenic RALY–USP22–c-Myc signalling axis and developed a therapeutic peptide that effectively suppresses tumour growth ⤵️
nature.com/articles/s41418-0…
“NF-κB inducing kinase (NIK) deletion accelerates KRAS-driven pancreatic cancer in association with tumor microenvironment remodeling”
Read more about this non-canonical NF-κB pathway in PDAC pathogenesis ⤵️
nature.com/articles/s41419-0…
“Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release”
A mechanistic insight into the intersection between mitochondrial function and innate immune activation ⤵️
nature.com/articles/s41418-0…
“GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4”
An intriguing oncogenic role for GSDME beyond its canonical pore-forming function in pyroptosis ⤵️
nature.com/articles/s41418-0…
“Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence”
An interesting link between lipid metabolism in OIS cells and their resistance to ferroptosis and oxidative stress ⤵️
nature.com/articles/s41418-0…
“The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway”
A comprehensive investigation into the protective role of the E3 ligase Itch in kidney fibrosis ⤵️
nature.com/articles/s41418-0…
“LSM7 coordinates scaRNA-mediated snRNA modification to ensure spliceosome fidelity and spermatogonial stem cell differentiation”
Mechanistic insights into post-transcriptional control of male germ cell development ⤵️
nature.com/articles/s41418-0…
“Transcription-coupled nucleotide excision repair protects against genomic instability and cell death induced by the liver toxin methyleugenol”
Read how TC-NER, rather than GG-NER, is crucial for resolving ME-induced DNA lesions ⤵️
nature.com/articles/s41419-0…
“Bon appétit, your phagocyte”
New perspective in CDDiscovery on how apoptotic cells undergo a meticulous ‘meal preparation’ process to be optimally suited for consumption by professional and non-professional phagocytes ⤵️
nature.com/articles/s41420-0…