The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
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Our June issue is now live.
The cover image puts microbes at play.
Have your own fun and enjoyment reading the content within:
cell.com/cell-host-microbe/c…
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Weekend read: Gut bacteria metabolize steroid hormones
Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including prednisolone. This microbial activity is enriched in Crohn’s disease & diminishes drug bioavailability
cell.com/cell-host-microbe/f…
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On the cover: Chutes & Ladders capture microbiome dynamics
Bacteria diversify into distinct subpopulations via epigenetic changes. Some are better adapted & “climb ladders,” thriving under stress; others succumb to “chutes” or stressors, e.g. antibiotics
cell.com/cell-host-microbe/a…
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NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back
Preview of work IDing aRES, bacterial proteins that deplete cellular NAD , generating products that cannot be utilized by phage NAD regeneration pathways
cell.com/cell-host-microbe/a…
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Bacteria vs phage: new layers in NAD centric arms race
aRES is bacterial protein that blocks phage infection by cleaving NAD into ADPR-1P & nicotinamide. Phages counter using NAD reconstitution pathway w/ADPR-1P & nicotinamide as substrates
cell.com/cell-host-microbe/a…
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Expanding role of the microbiome in GLP-1 pharmacology
Preview of work revealing the microbiome contributes to the psychological effects of glucagon-like peptide 1 (GLP-1) receptor agonists & discussion of these drug-microbe-host interactions.
cell.com/cell-host-microbe/a…
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Antidepressant effects of GLP-1 analogs mediated by microbes
Liraglutide reduces depression via GLP-1R-independent, microbiota-dependent mechanism. Liraglutide enriches L. delbrueckii, ⬆️endocannabinoid 2-AG to normalize activity in emotional brain regions
cell.com/cell-host-microbe/f…
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S. copri keeps pace with modern lifestyles
Subset of Segatella copri strains have acquired an additional oxygen regulator via horizontal gene transfer, which confers increased oxygen tolerance. These strains are more prevalent in industrialized countries
cell.com/cell-host-microbe/f…
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CoV protein interaction network in bats vs humans
Coronavirus-host interaction maps in human & bat cells uncover species-specific networks & single amino acid in Orf9b that differentially rewires host interactions that promote vs. limit infection
cell.com/cell-host-microbe/f…
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Co-opting cross-kingdom contact to boost bacterial pathogenicity
Preview of work evaluating bacterial-fungal co-infection of the female reproductive tract, revealing cross-kingdom co-infections can enhance pathogenicity & predisposition to infection.
cell.com/cell-host-microbe/a…
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Fungal pathobiont boosts Streptococcus
Fungal colonization primes group B strep pathogenic potential in vaginal tract via contact-dependent nutrient sharing. Interactions w/C. albicans promote bacterial adhesion & facilitate antibiotic evasion
cell.com/cell-host-microbe/a…
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Featured Article: Colorectal adenomas leave lasting microbiome imprint
Microbial alterations detectable >10 yr after adenoma resection that resemble those in colorectal cancer, suggesting sustained host-microbiome axis along adenoma-carcinoma continuum
cell.com/cell-host-microbe/f…
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Measles: Why the vaccine still works after 60 years
Preview of work demonstrating that vaccine-induced antibodies target highly conserved epitopes within the viral glycoproteins H and F, identifying a “vulnerability nexus” that ensures antigenic stability
cell.com/cell-host-microbe/a…
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Featured Article: Abs powering MMR efficacy against measles virus
Measles-specific mAbs isolated from human MMR vaccinee potently neutralize, target conserved sites & protect animals even after exposure, opening means to prevent/treat measles
cell.com/cell-host-microbe/f…
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Mother knows worms: Microbes pass on antiviral defense
Preview of work showing helminth-induced remodeling of maternal microbiota can program offspring’s antiviral immunity through a microbiota-derived metabolite that enhances lung IFN-I responses
cell.com/cell-host-microbe/a…
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Featured Article: Mom’s helminths rewire microbiota to protect offspring
Maternal helminths confer protection against respiratory viruses in offspring. Helminth-induced changes in microbiota increase indole-3-propionic acid, which induces lung IFN-I
cell.com/cell-host-microbe/f…
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Cell Host & Microbe retweeted
Here the authors present evidence in mice that liraglutide promotes anti-depressant actions independent of the GLP-1R by modulating a microbiota-endocannabinoid metabolic pathway, revealing a potential therapeutic target for depression @cellhostmicrobe cell.com/cell-host-microbe/f…
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Cell Host & Microbe retweeted
Jun 10
Some people taking GLP-1 drugs have experienced decreased symptoms of depression. Mouse study reveals this may be connected to GLP-1's impact on the gut microbiome.
Learn more in @cellhostmicrobe: cell.com/cell-host-microbe/f…
Honghong Yao & colleagues
ALT graphical abstract
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Cell Host & Microbe retweeted
Jun 10
Our new paper co-led with BGI and IOCAS (Qingdao) just out @cellhostmicrobe
The genetic repertoire of deep-sea #microbiome: from sequence to structure and function.
@micronorwich @UEA_COAS @uniofeastanglia
sciencedirect.com/science/ar…
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Cell Host & Microbe retweeted
Jun 7
Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice. Researchers from @ShandongU report in @Cellhostmicrobe #ASMicrobe hubs.li/Q04k7ZSM0
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