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Cell Reports @CellReports

Cell Reports is an open-access journal at Cell Press, publishing weekly. Tweets by Cell Reports editors.

Joined July 2011
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Join us in Seville, Spain, October 4–6, to explore the latest advances in aging biology, healthspan, and resilience with researchers from around the world. #CSAging2026. Featuring keynote Luigi Ferrucci (@NIHAging). Extended abstract deadline June 26. hubs.li/Q04lz9D40
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SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer dlvr.it/TT485N

SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer

Pancreatic cancer stem cells drive progression and therapy resistance. Krishna Kumar et al. show that SLC22A3/OCT3 sustains serotonin-mediated stemness in pancreatic cancer. Genetic and pharmacologic...

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Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis dlvr.it/TT42cw

Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation...

Roostaei et al. define cell-type- and state-specific transcriptional programs associated with immune dysregulation in multiple sclerosis. Integrating purified immune cell transcriptomics, network...

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Piezo2 tension sensitivity and its modulation by alternative splicing dlvr.it/TT3z8g

Piezo2 tension sensitivity and its modulation by alternative splicing

Sindoni and colleagues demonstrate that alternative splicing modulates the sensitivity of the force-gated ion channel Piezo2. They identify exon 35 as a domain sufficient for maximal mechanical...

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Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex dlvr.it/TT3vC8

Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in...

(Cell Reports 44, 115162; January 28, 2025)

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Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos dlvr.it/TT3TTv

Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects...

(Cell Reports 39, 110784; May 3, 2022)

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IL-33/TGF-β/IL-4-induced bone marrow-derived DC9 subset promotes Th9 differentiation and allergic airway inflammation dlvr.it/TT3NyN

IL-33/TGF-β/IL-4-induced bone marrow-derived DC9 subset promotes Th9 differentiation and allergic...

Chen et al. demonstrate that IL-33, TGF-β, and IL-4 drive bone marrow-derived DCs to differentiate into DC9, a novel IL-9 secreting subset, through the JAK-STAT6-IRF4 pathway. DC9 cells are detected...

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A cross-vertebrate brain protein interaction map identifies conserved neural and non-neural complexes dlvr.it/TT3LPs

A cross-vertebrate brain protein interaction map identifies conserved neural and non-neural...

Dang et al. use co-fractionation and immunoprecipitation mass spectrometry to map protein interactions conserved across vertebrate brains. This resource, dubbed VerteBrain, offers insights into brain...

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Anterior lateral motor cortex enables contextual decision-making via dynamic reconfiguration of local circuits dlvr.it/TT3CdF

Anterior lateral motor cortex enables contextual decision-making via dynamic reconfiguration of...

During context-dependent decision-making, anterior lateral motor cortex is required to configure stimulus-response mappings. Two-photon imaging reveals neurons that jointly encode context and choice,...

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The C-terminal region of TENT5 proteins drives ER-associated mRNA polyadenylation via FNDC3 interaction dlvr.it/TT35ys

The C-terminal region of TENT5 proteins drives ER-associated mRNA polyadenylation via FNDC3...

Viviani et al. identify the molecular determinants that recruit TENT5 poly(A) polymerases to the endoplasmic reticulum. A divergent C-terminal region mediates interaction with FNDC3 proteins,...

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Elevated phagocytic capacity directs innate spinal cord repair dlvr.it/TT32nq

Elevated phagocytic capacity directs innate spinal cord repair

Klatt Shaw et al. report that transient activation of zebrafish macrophages directs spontaneous regeneration after spinal cord injury. By comparing regenerative and non-regenerative vertebrates, they...

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Catalytic footprints of DNMT1 dynamics during mammalian cell state transitions dlvr.it/TT2z4Q

Catalytic footprints of DNMT1 dynamics during mammalian cell state transitions

Stankevičius et al. report mono-allelic engineering of mESCs enabling DNMT1 catalysis-dependent tagging of genuine target sites upon internalization of a synthetic cofactor analog. Genomic mapping of...

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Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation dlvr.it/TT1M3d

Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated...

Kostas et al. show that elevated inorganic phosphate induces a mitochondria-derived hydrogen peroxide burst that triggers activation of FGFR1 via oxidation of key residues in the kinase domain. This...

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Cisplatin resistance in an ovarian cancer model is mediated by microtubule dynamics regulator TPPP3 in synergy with tubulin code rewiring dlvr.it/TT1Gqc

Cisplatin resistance in an ovarian cancer model is mediated by microtubule dynamics regulator TPPP3...

Horibata et al. show that the cancer drug cisplatin destabilizes microtubules by accelerating loss of the GTP cap and identify tubulin polymerization-promoting protein 3 (TPPP3) as a microtubule...

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Aging restricts maturation of CXCL13 T follicular helper cells in human immunity dlvr.it/TT1DZ1

Aging restricts maturation of CXCL13 T follicular helper cells in human immunity

Bracey et al. show that impaired antibody responses with age are primarily driven by defective T follicular helper cell maturation rather than intrinsic B cell dysfunction. They identify loss of...

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A conserved antioxidant defense at the endoplasmic reticulum membrane dlvr.it/TT15cY

A conserved antioxidant defense at the endoplasmic reticulum membrane

Ji et al. identify ERGU-1/TMEM161B as an evolutionarily conserved ER-transmembrane protein that modulates oxidative stress generated during oxidative protein folding. This critical guardian maintains...

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Socially shared emotions shape the activity of the medial prefrontal cortex during inference of others’ emotional states dlvr.it/TT10g3

Socially shared emotions shape the activity of the medial prefrontal cortex during inference of...

People differ in how they interpret social situations and infer others’ emotions. This fMRI study shows that the medial prefrontal cortex integrates this social variability to infer others’ emotional...

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KRAS4A promotes oligomerization of hexokinase 1 on mitochondria dlvr.it/TT0xY0

KRAS4A promotes oligomerization of hexokinase 1 on mitochondria

Hexokinase 1 (HK1) associates with the outer mitochondrial membrane (OMM) where its allosteric regulation depends on oligomerization. KRAS4A interacts with HK1 on the OMM and enhances its catalytic...

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A progenitor cell population contributes to prenatal injury repair and neonatal antimicrobial defense in the small intestine dlvr.it/TT0sdw

A progenitor cell population contributes to prenatal injury repair and neonatal antimicrobial...

Shen et al. report a population of small intestinal sentinel progenitor cells (SISPCs), marked by Lysozyme1 in the embryonic and neonatal mouse small intestine. SISPCs display stemness potential in...

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Nerve-proximal tertiary lymphoid structures predict chemotherapy sensitivity in pancreatic cancer dlvr.it/TT0RDS

Nerve-proximal tertiary lymphoid structures predict chemotherapy sensitivity in pancreatic cancer

Cai et al. investigate how neural remodeling shapes antitumor immunity following neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma. They find that chemotherapy induces Schwann cell...

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