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Core Step Prep @corestepprep

USMLE QBank for Step 1 & Step 2CK. Modeled on NBME exams. Study what actually matters, no fluff. Now available on the Apple App Store. #CoreStepPrep

Joined September 2025
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12 Photos and videos
Freediver plunges into icy water; HR drops while MAP rises to preserve brain flow. Which autonomic reflex best explains the bradycardia? A) Trigeminal-vagal B) Baroreceptor unloading C) Bainbridge reflex D) β1 upregulation #CoreStepPrep #USMLE #MedStudent #MedSchool
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19F perfumer trainee: amenorrhea anosmia; MRI absent olfactory bulbs. Failed puberty is due to which defect? A) GnRH neuron migration B) Aromatase excess C) 5α-reductase deficiency D) Leydig cell aplasia #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Toddler: coarse facies, cloudy corneas, ↑ plasma lysosomal enzymes; fibroblasts have inclusions. Failed step? A) M6P tag in Golgi B) COPII budding from ER C) Importin nuclear entry D) Clathrin uncoating #CoreStepPrep #USMLE #MedStudent #MedSchool
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Ultramarathoner pops ibuprofen, then gets oliguria bland urine after a GI bug. Which renal hemodynamic change best explains ↓GFR? A) Afferent constriction B) Efferent dilation C) ↑Mesangial relax D) ↑Kf #CoreStepPrep #USMLE #MedStudent #MedSchool
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Postpartum pt insists her baby was swapped by an identical impostor; neuro exam normal. Which misidentified link is disrupted? A) Face recognition-affect B) Hippocampal-LTP C) Broca-Wernicke D) Papez olfaction #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Age 4: vaginal bleeding jagged café-au-lait; LH/FSH low. Ovarian cells bypass axis control. Defect? A) Gsα locked on B) Giα locked on C) JAK-STAT gain D) IP3/Ca loss #CoreStepPrep #USMLE #MedStudent #MedSchool
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Teen fencer has anosmia, no puberty; LH/FSH low despite normal pituitary MRI. What failed embryologic event? A) GnRH neuron migration B) POMC cleavage C) Thyroglobulin iodination D) 21-hydroxylation #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Falconer on steroids: brain abscess cavitary pneumonia; sputum has branching weakly acid-fast rods. Host defect raising risk? A) NADPH oxidase B) C5-C9 deficiency C) IgA deficiency D) TLR4 mutation #CoreStepPrep #USMLE #MedStudent #MedSchool
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Post-BCG infant has disseminated mycobacteria; DHR normal. Defective pathway? A) IL-12→IFN-γ axis B) C5-9 MAC assembly C) CD40L switching D) AIRE deletion #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Infant w anemia, fractures & CN palsies has marble-dense bones; osteoclasts present but lacuna acidification fails. Defect? A) Carbonic anhydrase II B) Type I collagen C) RANKL signaling D) ALP mineralization #CoreStepPrep #USMLE #MedStudent #MedSchool
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Newborn has choking/cyanosis with feeds; NG tube coils in upper pouch, gas in stomach. Which embryologic error? A) TE septum deviation B) Urachus persistence C) Failed midgut return D) Vitelline duct remnant #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Dialysis pt opens a new AV fistula; minutes later HR rises and MAP falls despite ↑venous return. Which change drives ↑CO? A) ↓TPR B) ↑Afterload C) ↓Contractility D) ↑Blood viscosity #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Floppy newborn later has hyperphagia & obesity. Two intact chr15s are both maternally derived. Mechanism? A) Uniparental disomy B) Anticipation C) Loss of imprinting D) Trinucleotide repeat #CoreStepPrep #USMLE #MedStudent #MedSchool
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Newborn drools/chokes w feeds; prenatal polyhydramnios gastric air. Failed partitioning of which embryonic structure? A) TE septum B) Urorectal septum C) Septum transversum D) Neural crest #CoreStepPrep #USMLE #MedStudent #MedSchool
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17M with delayed puberty, small testes, and no axillary hair can't smell burnt popcorn after a dorm microwave fiasco. Expected pattern? A) ↓ pulsatile GnRH B) ↑ inhibin B C) ↑ testosterone D) ↑ LH surges #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Teen has woolly hair, palmoplantar keratosis & exertional syncope; RV fibrofatty change suggests Naxos dz. Mutated junctional protein? A) Plakoglobin B) Integrin α6β4 C) Keratin 14 D) Connexin 26 #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Arizona spelunker has fever, erythema nodosum, hilar LAD; spherules packed with endospores in tissue. Which lab form is infectious? A) Arthroconidia B) Spherules C) Budding yeast D) Germ tubes #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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Teen with eczema, staph cold abscesses, pneumatoceles, scoliosis & retained baby teeth has very high IgE. Which defect drives poor Th17 differentiation? A) STAT3 B) BTK C) WASp D) CD18 #CoreStepPrep #USMLE #MedStudent #MedSchool #Step1
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29F has RUQ pain, hepatic vein thrombosis, pancytopenia, and cola-colored morning urine. Flow cytometry shows ↓CD55/59. Defect? A) GPI anchor synthesis B) β-globin splicing C) Ankyrin-spectrin D) ADAMTS13 cleavage #CoreStepPrep #USMLE #MedStudent #MedSchool
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NICU resident has intrusive fear she'll drop a preemie; checking incubator latch 20x briefly eases dread. What maintains ritual? A) Neg reinforcement B) Pos reinforcement C) Extinction D) Punishment #CoreStepPrep #USMLE #MedStudent #MedSchool
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