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Corey Griffith @coreymgriffith

Metabolic Biochemist. Interested in problems that intersect analytical chemistry, metabolism, toxicology, and the environment. 🇺🇸 in 🇱🇺

Joined December 2016
  • Tweets 254
  • Following 533
  • Followers 222
48 Photos and videos
#MetaboliteRepair enzymes have evolved to eliminate often toxic non-canonical metabolites. Out today in @nchembio, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion doi.org/10.1038/s41589-025-0…

CLYBL averts vitamin B12 depletion by repairing malyl-CoA

Nature Chemical Biology - CLYBL has a role beyond itaconate catabolism to degrade malyl-CoA, a noncanonical metabolite and methylmalonyl-CoA mutase inhibitor that depletes coenzyme B12, implying...

nature.com
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Happy to share this preprint of my postdoc work on discovering that CLYBL repairs malyl-CoA to avert methylmalonyl-CoA mutase inhibition and loss of vitamin B12! Thanks to the team for all your help! #MetaboliteRepair biorxiv.org/content/10.1101/…
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Looking forward to this afternoon's session on "Enzymatic control of problematic intermediates" at #DiscoverBMB! Three metabolite repair talks in a session - this may be a record!
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Corey Griffith retweeted
Kermit Murray@kermitmurray
14 Feb 2024
(Nature MS) A spectroscopic test suggests that fragment ion structure annotations in MS/MS libraries are frequently incorrect dlvr.it/T2lZ8j (RSS) #nature #MassSpecRSS
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Tom Niehaus@TomDNiehaus
29 Jan 2024
The TCA cycle is fraught with metabolite damage. Here we describe a universal repair enzyme that prevents the TCA cycle from poisoning itself: link.springer.com/10.1038/s4…

A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle

Nature Communications - Succinate dehydrogenase converts malate to enoloxaloacetate, a metabolically inactive and inhibitory side product of the TCA cycle. Here, Zmuda et al. describe a conserved...

link.springer.com
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LifeScienceAlliance@LSAjournal
10 Jan 2024
Zebrafish model for CLN3 Batten disease recapitulates the human metabolic signatures of BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at larval stages life-science-alliance.org/co…
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Ralser Lab@RalserLab
20 Nov 2023
biorxiv.org/content/10.1101/… Nice follow up by @mdtauqeer on his earlier work on enzyme inhibition doi.org/10.1038/ncomms16018, now showing how frequent metabolic enzyme activators let metabolic pathways talk to each other

An enzyme activation network provides evidence for extensive regulatory crosstalk between metabolic...

Enzyme activation by cellular metabolites plays a pivotal role in regulating metabolic processes. Nevertheless, our comprehension of such activation events on a global network scale remains incompl...

biorxiv.org
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So very proud of my friend and colleague, Lorenzo! Congratulations! 🥳
Emma Schymanski@ESchymanski
25 Oct 2023
Congratulations to Dr. Lorenzo Favilli - second ECI and ECHIDNA PhD graduate. We are all so proud of you! #proudPI #metabolomics #TeamMassSpec @lcsb_uni_lu @uni_lu @FnrLux @ResearchLux Here with Carole Linster and @coreymgriffith Many thanks to our Jury & audience as well!
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Congrats on the promotion @ESchymanski!! 🎉🥳
Emma Schymanski@ESchymanski
20 Oct 2023
What a great team! #environmental #cheminformatics @lcsb_uni_lu @EmmaPalm4 @DagnyAurich Federica Vero @HibaMohamedTaha @AnjuAnjuraj15 @Begotalavera9 Camilla @PChirsir Lorenzo @coreymgriffith (out of pic @GianfrancoFrig1 )
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Emma Schymanski@ESchymanski
20 Oct 2023
What a great team! #environmental #cheminformatics @lcsb_uni_lu @EmmaPalm4 @DagnyAurich Federica Vero @HibaMohamedTaha @AnjuAnjuraj15 @Begotalavera9 Camilla @PChirsir Lorenzo @coreymgriffith (out of pic @GianfrancoFrig1 )
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Emma Schymanski@ESchymanski
4 Aug 2023
Interested in rare diseases, mitochondria, non-target mass spectrometry #TeamMassSpec #cheminformatics and identification? Exciting #postdocposition in GENOMIT consortium with rare disease cohort at @lcsb_uni_lu @uni_lu in the Linster & Schymanski groups! emea3.mrted.ly/3fyae
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Emma Schymanski@ESchymanski
25 Jul 2023
Come join us! We are looking for a Postdoctoral Researcher in Mass Spectrometry Workflows for Unknown Chemicals to join the Environmental Cheminformatics group at @lcsb_uni_lu @uni_lu #TeamMassSpec #cheminformatics #OpenScience Interested? Apply here⬇️ emea3.mrted.ly/3h2lg
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Anal Bioanal Chem@AnalBioanalChem
18 Jul 2023
High-throughput Saccharomyces cerevisiae cultivation method for credentialing-based untargeted #metabolomics by Lorenzo Favilli et al @lcsb_uni_lu @uni_lu @ESchymanski @coreymgriffith #yeast #chromatography #labelling #spectrometry #OpenAccess link.springer.com/article/10…
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laura martinelli@martinelli7512
5 Jul 2023
A real @fonia_sin led by our coordinator @PabloINik ! In front of the Opera House in the eternal city, in the occasion of our final meeting, but is it so? I doubt it 😎 we will continue playing 🙌🏻
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Corey Griffith@coreymgriffith
24 Apr 2023
Come be a split EM/ECI postdoc like me! This is a very cool project for those interested in unknown identification.
Emma Schymanski@ESchymanski
24 Apr 2023
If you are interested in a PostDoc for targeted and untargeted #metabolomics #TeamMassSpec for mitochondrial disorders working with these two groups at @lcsb_uni_lu @uni_lu funded by @FnrLux as part of the GENOMIT consortium, please apply here: emea3.mrted.ly/3dsa5
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Pass this immediately!
Gavin Newsom
@GavinNewsom
8 Jun 2023
NEW: I’m proposing the 28th Amendment to the United States Constitution to help end our nation’s gun violence crisis. The American people are sick of Congress’ inaction. The 28th will enshrine 4 widely supported gun safety freedoms -- while leaving the 2nd Amendment intact: 1) Raising the minimum age to purchase a gun to 21 2) Universal background checks 3) A reasonable waiting period for gun purchases 4) Banning the civilian purchase of assault weapons
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Anal Bioanal Chem@AnalBioanalChem
30 May 2023
Thank you very much @ESchymanski @coreymgriffith Lorenzo and Carole for submitting your work to ABC! @GNPS_UCSD @lcsb_uni_lu @uni_lu @FnrLux #metabolomics
Emma Schymanski@ESchymanski
22 May 2023
Super #proudPI tonight to see Lorenzo's work with Carole Linster and @coreymgriffith now published - high throughput stable labeling approach for untargeted metabolomics in yeast, all data in @GNPS_UCSD and more! @lcsb_uni_lu @uni_lu @FnrLux #OpenScience link.springer.com/article/10…
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Many congrats to Lorenzo and the entire team! Credentialing is a powerful yet unexploited branch of metabolomics and herein, we devised a nice approach to help tackle these projects in yeast.
Emma Schymanski@ESchymanski
22 May 2023
Super #proudPI tonight to see Lorenzo's work with Carole Linster and @coreymgriffith now published - high throughput stable labeling approach for untargeted metabolomics in yeast, all data in @GNPS_UCSD and more! @lcsb_uni_lu @uni_lu @FnrLux #OpenScience link.springer.com/article/10…
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Corey Griffith retweeted
Robert Jansen@Robert_S_Jansen
3 May 2023
We are looking for a PhD candidate who is enthusiastic about discovering the function of enzymes and metabolites in Mycobacterium tuberculosis using genetic screens and untargeted metabolomics. Interested? Please apply before May 26th! ru.nl/en/working-at/job-oppo… #jebentnodig

Job opportunities | Radboud University

Come work at Radboud University. Take a look at our scientific and non-scientific vacancies.

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