Joined July 2012
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Pinned Tweet
9 Oct 2024
My doctoral advisor @UWMolES / @UWproteindesign (and current scientific advisory board membe @Xaira_Thera) David Baker won the nobel prize!! So stoked and extremely determined to deliver on the promise of this tech! nobelprize.org/prizes/chemis…
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5 Nov 2025
Glad to see our antibody design paper finally out in @Nature (and congrats to lead authors and everyone involved )!
At @Xaira_Thera we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs.
Paper:
nature.com/articles/s41586-0…
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26 Sep 2025
Showcase of #proteindesign possibilities why they matter!
- minibinders (rigid fusions; composability with other denovo designs)
- tunable biophysical properties (modulate k_off, flexibility, strain)
- #crispyshifty hinges (allosteric control of binding kinetics to native target)
24 Sep 2025
We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.
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26 Sep 2025
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Phil Leung retweeted
11 Jul 2025
We searched for Bigfoot using CRISPR. DNA storage meets CRISPR search: AI maps the data, Cas9 slices it, nanopores read it. Multiplexed molecular search with semantic retrieval across a database of DNA-encoded images. Off-targets = a feature, not a bug. tinyurl.com/mr34c7fh
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Phil Leung retweeted
17 Jan 2025
Thrilled to share our latest publication in Nature: nature.com/articles/s41586-0…. This work reflects a fantastic collaboration—special thanks to David Baker and @TimothyPJenkins. Hoping it sparks attention to this neglected health issue and drives solutions in the years ahead!
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11 Dec 2024
What an immense privilege to celebrate the #NobelPrize with David, former colleagues from @UWproteindesign , current colleagues at @Xaira_Thera and @RosettaCommons family!
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20 Nov 2024
So cool to see #CrispyShifty hinges applied this way! Congrats @adam_broerman
17 Nov 2024
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.1101/…
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Phil Leung retweeted
17 Nov 2024
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.1101/…
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Phil Leung retweeted
12 Nov 2024
I guess errors are expected. But it does highlight the need for journals to require depositing source code before publication.
12 Nov 2024
After taking a look at af3 released code… looks there are some differences to the Nature report😉 @maxjaderberg @pushmeet
Also reported here github.com/bytedance/Proteni…
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Phil Leung retweeted
10 Oct 2024
⚛️ I got a new job ⚛️
After 5 wonderful years at @UWproteindesign and @UWMolES, I’m headed to Palo Alto for a postdoc at @StanfordUChem under Todd Martinez.
SUPER excited to dive into deep learning for quantum chemistry and explore the Bay Area!!
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Phil Leung retweeted
9 Oct 2024
Nobel Laureate David Baker on the phone with fellow awardees Demis Hassabis and John Jumper. The trio discussed how their teams have inspired one another and what the future may hold.
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9 Oct 2024
My doctoral advisor @UWMolES / @UWproteindesign (and current scientific advisory board membe @Xaira_Thera) David Baker won the nobel prize!! So stoked and extremely determined to deliver on the promise of this tech! nobelprize.org/prizes/chemis…
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9 Oct 2024
#CrispyShifty proteins mentioned - highlight of the announcement for me 😁 @ArvindSPillai1 @FloPraetorius
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11 Sep 2024
Congrats!!
11 Sep 2024
Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s41586-0…
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15 Aug 2024
Love this article by @schubertcm @geekwire on what we're trying to do here in #Seattle at @Xaira_Thera @JustasDauparas @naterbennett0 geekwire.com/2024/inside-the…
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Phil Leung retweeted
14 Aug 2024
Excited to announce our new paper on designing allosterically regulated protein assemblies from scratch, now published in @Nature! This collaborative effort included key contributions from @FloPraetorius, Abbas Idris, @AnnikaPhilomin, @cweidle1 and others! nature.com/articles/s41586-0…
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14 Aug 2024
Awesome paper in @Nature! @ArvindSPillai1 achieved theoretically perfect ligand binding cooperativity with a hill coefficient of ~4 (hemoglobin is ~2.8 by comparison). Congrats Arvind, Abbas, @FloPraetorius and team, truly an honor to help with this work: nature.com/articles/s41586-0…
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Phil Leung retweeted
14 Aug 2024
Hot off the press: New paper about computational design of oligomeric proteins that can be triggered to change size and shape through allostery. Check out the beautiful thread by @ArvindSPillai1 !
14 Aug 2024
Excited to announce our new paper on designing allosterically regulated protein assemblies from scratch, now published in @Nature! This collaborative effort included key contributions from @FloPraetorius, Abbas Idris, @AnnikaPhilomin, @cweidle1 and others! nature.com/articles/s41586-0…
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14 Aug 2024
Congrats @SusanaVazTor it was an honor to work with you in grad school!
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