The best part of being an adult is realizing nobody can stop you from spending $1,000 on a lazy river for your backyard. As kids we dreamed about this stuff. As adults we call it “financial planning.”

🤯 JUST IN: INCREDIBLE PHASE 3 DATA ON RETATRUTIDE PRESENTED AT ADA At ADA this weekend, Eli Lilly ($LLY ) presented new Phase 3 data from TRIUMPH-1 and TRANSCEND-T2D-1. BLUF: 28% (70 pounds) weight loss. Unreal. In TRIUMPH-1, participants receiving 12 mg of retatrutide lost an average of 70.3 pounds (28.3%) over 80 weeks. Nearly half achieved at least 30% weight loss, and 65.3% were no longer classified as obese (BMI <30) by the end of the study. Among participants who started with BMI ≥35 and continued treatment to 104 weeks, average weight loss reached 85 pounds (30.3%), with no evidence that weight loss had fully plateaued. What stood out more was the breadth of effect across obesity-related conditions: Knee osteoarthritis pain improved by 73.1% Obstructive sleep apnea severity improved by 60.6% Triglycerides fell by as much as 41.0% Non-HDL cholesterol declined by 24.2% Systolic blood pressure dropped by 12.3 mmHg Waist circumference decreased by 9.5 inches Meanwhile, in TRANSCEND-T2D-1, retatrutide produced A1C reductions of up to 2.0% from a baseline of 7.9%. 90% of patients achieved A1C <7% 85% achieved A1C ≤6.5% 46% reached A1C <5.7%, which is below the threshold used to define prediabetes Patients lost 36.6 pounds (16.8%) at 40 weeks, and weight loss was still ongoing at study end. Obesity medicine is increasingly becoming outcomes medicine. Historically, we have evaluated obesity drugs primarily on percent weight loss... but payers ultimately care about sleep apnea, osteoarthritis, diabetes, cardiovascular risk, and healthcare costs. The significance of TRIUMPH-1 and TRANSCEND-T2D-1 is that Lilly is beginning to show a coherent story across those endpoints, not just body weight. I expect this to expand coverage dramatically. Eli Lilly is the Nvidia of healthcare.

To me, Photon is such an obvious thing that should exist in healthcare Instead of doctors calling a bunch of pharmacies individually and coordinating your prescription, they send the prescription to a wallet the patient controls. Then the patient can choose which pharmacy to send it to, and can shop around with that prescription. I usually don't shill portcos like this, but I don't think they get enough shine tbh

Thanks to the @oasishealthapp I’ve switched from poisonous FairLife Protein Milk to Bourbon and I can’t even begin to explain how much healthier I feel.

In some very real sense, Ozempic was invented in 1990. Pfizer ran the human trials and just never published them. They showed it lowered blood glucose in diabetics, slowed gastric emptying, and killed hunger; the same 3 things that make Ozempic work today. The joint venture agreement said internal data stayed internal, and that was that. Pfizer killed the program in 1991. The reasoning, as far as I can tell, was that nobody would ever want an injectable diabetes drug besides insulin. So, the license went back to the hospital in Boston that held the patents. Novo picked it up in 1992 and spent the next two decades building liraglutide, then semaglutide. It's insane that data sat in a filing cabinet for 30 years. I only know this because Jeffrey Flier, one of the Harvard scientists in the room, finally wrote it up. He's in his late 70s and didn't want the history to die with him. This makes you wonder what else is in those filing cabinets. Ozempic could've existed 27 years ago.

“We did the hardest thing in the history of American health care. We got the majority of American doctors to all voluntarily adopt a single technology platform.” NBC News on how that happened, what U.S. physicians actually do with OpenEvidence, and how partnerships with NEJM, JAMA, NCCN, and Wiley make it possible.

Three straight years of drug overdose declines wsj.com/health/us-drug-overd…

New study shows how impactful at-home remote monitoring can be as healthcare (finally) moves to more of a continuous care model sciencedirect.com/science/ar…

Forus announces a $160M fundraise to accelerate getting the most innovative, best treatments to the right patients (by embedding itself into provider workflows) forus.com/blog/forus-announc…

You can buy AG1 at Ulta now athletechnews.com/ag1-lands-…

Lifeway announces a killer Q1 driven mostly by kefir and other high-protein products, explicitly citing GLP-1 users as a key demo prnewswire.com/news-releases…

Obesity continues to grow in most countries... minus a few wealthy ones statnews.com/2026/05/13/obes…

Hyrox officially has added kids to its races hyrox.com/hyrox-youngstars

There's a "dairy relief" fast-acting lactase digestion patch mybarriere.com/products/dear…

This is it. Everything learned spending millions on longevity. From: Your Immortal Unc and Auntie. To: Our Immortal nieces and nephews. 0. Sleep is the world's most powerful drug. 1. Be in your bed for 8 hours 2. Same bedtime every night, any time before midnight 3. Don’t eat right before bed 4. Calm foods for dinner 5. No screens 1 hour before bed 6. Avoid added sugar (be aware it’s in everything) 7. Avoid all things in an American convenience store 8. Avoid fried foods 9. Shoes off at the door 10. Eat whole foods, particularly veggies fruits nuts legumes berries 11. Walk a little after meals or air squats 12. Get your heart rate high routinely 13. Lift heavy things 14. Stretch daily 15. Water pik, floss, brush, tongue scrape, morning and night 16. Make an effort to drink water 17. Get sunlight when you wake up (UV is low) 18. Protect skin in midday sun 19. Stand up straight 20. See at least one friend once a week 21. Avoid plastic where you can (in all things) 22. Circulate air in rooms 23. When stressed, breathe, learn to calm your body 24. Go to the dentist 25. Avoid sitting for long times 26. Protect your hearing, the world is too loud 27. Alcohol is bad for you 28. Finish coffee before noon 29. Avoid bright lights after sunset 30. If obese, look into a GLP 31. Sleep in a cold room 32. Texting while driving is dangerous 33. Turn off all notifications 34. Limit social media use 35. Don’t smoke anything 36. If you struggle to sleep, read a physical book before bed 37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music 38. The body is a clock and loves routine. Have a daily morning and evening schedule. 39. Avoid long distance travel where you can 40. Baby steps first: incorporate new things slowly 41. Do less… most things don’t work. Bonus points if you get your blood checked. Start here, it will change your life.

PCOS has a new official name endocrine.org/news-and-advoc…

Function acquires SuppCo! supp.co/articles/founders-no…

Meet "Trimester Zero" for the period pre-pregnancy nytimes.com/2026/05/12/magaz…

Wearables making big leap into proactive health bloomberg.com/news/features/…

Super interesting data on increasing LLM use for health stuff rockhealth.com/insights/the-…