@dngman profile picture
Denis A. Engemann @dngman

Neuroscientist in Pharma R&D @Roche. Passionate about brains, machine learning, metabolism, health, nutrition ... cycling. Tweets = personal views & opinions.

Joined June 2013
  • Tweets 1,954
  • Following 2,155
  • Followers 2,106
205 Photos and videos
Pinned Tweet
Denis A. Engemann@dngman
1 Apr 2025
šŸ©ŗšŸ§  āœØ Excited about our latest work published in @eBioMedicine! In the BioFIND dataset, we found that brain activity provided unique information about progression to Alzheimerā€™s Disease (AD). Paper: thelancet.com/journals/ebiomā€¦; Thread šŸ§¶ ā¤µļø
4
3
13
919
Join our team as a 12-month PhD intern @ Roche (Basel)! šŸ§  Project: Use causal inference & ML on proteomics to find causal drivers of Alzheimer's. For: 3rd-year PhD candidates #Genomics #MachineLearning #CausalInference #CompBio #Alzheimers See details & apply below ā¬‡ļø
1
1
5
337
See details and apply here: careers.roche.com/global/en/ā€¦
105
Denis A. Engemann retweeted
Jake Scott, MD
@jakescottMD
1 Sep 2025
Replying to @SecKennedy
Pfizerā€™s COVID data isnā€™t hidden. Itā€™s been reviewed by FDA, published in peer-reviewed journals, analyzed worldwide, and tracked in millions of people through real-world safety and effectiveness studies. Pretending otherwise is gaslighting, not ā€œgold standard science.ā€
66
103
1,182
18,103
Denis A. Engemann retweeted
Andrea C. Love, PhD@dr_andrealove
31 Aug 2025
RFK Jr cut half a billion dollars in research funding for mRNA vaccines. He & Marty Makary claim mRNA vaccines are ā€œriskyā€ so theyā€™ll shift to ā€œtraditional, olderā€ vaccine tech thatā€™s ā€œsafer.ā€ We used to immunize people by blowing powdered smallpox scabs up their noses. 1/
40
542
2,400
45,797
Denis A. Engemann retweeted
Jake Scott, MD
@jakescottMD
30 Aug 2025
Replying to @stella_immanuel
People donā€™t wear seatbelts because they prevent all crashes. They wear them because they reduce the risk of death in a crash. COVID vaccines work the same way: they donā€™t stop every infection, but they dramatically reduce severe disease and death. And theyā€™re not unsafe.
13
15
109
2,833
Denis A. Engemann retweeted
Steve Magness
@stevemagness
28 Aug 2025
RFK Jr. saying "mitochondria challenge" is a perfect illustration of our time. It sounds sciency. But it's meaningless. It's jargon to create the illusion of knowledge. You see this ALL the time in the pseudo health world. And research shows it works to fool others
18
22
284
18,783
Denis A. Engemann retweeted
Dr. Angela Rasmussen
@angie_rasmussen
26 Aug 2025
The MAHA assault on vaccines will kill people & usher in a scientific Dark Age. RFK Jr has got to go. Join me, my fellow Accountability Journalism institute advisors, Nobel laureates, National Academy members, & colleagues demanding his resignation. change.org/p/demand-rfk-jr-rā€¦

Sign the Petition

Demand RFK Jr. Resign: Petition for a Healthy America

change.org
145
384
1,406
92,187
Denis A. Engemann retweeted
Gael Varoquaux šŸ¦‹@GaelVaroquaux
20 Aug 2025
Our didactic review on machine learning for causal inference, now open access We explain ā€¢ identifiability (theory of when the data can answer a causal question) ā€¢ machine-learning estimators ā€¢ study design (asking well-framed questions, and loopholes, eg with time-wise data)
3
15
76
4,746
Gorgeous city of Firenze during 12k pre-breakfast run, getting sunlight and downloading good mood before diving into my day šŸ‘ŸšŸ’Øā˜€ļø
5
269
Denis A. Engemann retweeted
Marc Aurel Busche@marcaurelbusche
8 May 2025
Where does Alzheimerā€™s begin in the brain? Our new study in @NeuroCellPress reveals that earliest changes start deep in cortical layers 5/6, selectively affecting parvalbumin interneurons via reduced NPTX2 & GluA4. Restoring NPTX2 reversed deficits. cell.com/neuron/fulltext/S08ā€¦

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimerā€™s disease...

Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged Ca2 transients early in Alzheimerā€™s mouse models. This is linked to suppressed activity and altered tuning of...

cell.com
6
63
225
19,540
šŸšØ Preprint Alert šŸ”” Does EEG brain-age work as a neurodegeneration biomarker? Brain age was surprisingly under-predicted in neurological populations. Likely due to diverging age trends in EEG power, breaking model assumptions. Preprint: biorxiv.org/content/10.1101/ā€¦ #biomarker #EEG
Figure 4 from our preprint, proposing a theoretical model for why EEG and other brain-activity measures might deliver inaccurate or surprising and pradoxical brain-age estimates.

ALT Figure 4 from our preprint, proposing a theoretical model for why EEG and other brain-activity measures might deliver inaccurate or surprising and pradoxical brain-age estimates.

1
2
11
631
šŸ©ŗšŸ§  āœØ Excited about our latest work published in @eBioMedicine! In the BioFIND dataset, we found that brain activity provided unique information about progression to Alzheimerā€™s Disease (AD). Paper: thelancet.com/journals/ebiomā€¦; Thread šŸ§¶ ā¤µļø
4
3
13
919
more replies
9/ Worried about site effects, controlling for MMSE, spatial averaging, impact of head alignment or comparisons VS healthy controls / cortical slowing? We got you covered by a dozen of supplementary analyses: thelancet.com/cms/10.1016/j.ā€¦
1
2
119
10/ Thanks to all study participants and involved family members, @DPUKDataPortal for providing data access! Big shout out to all co-authors: Sinead Gaubert (lead!), Pilar Garces, Jƶrg Hipp, Ricardo BruƱa, Maria Eugenia LopƩz, Fernando Maestu, Delshad Vaghari, Rik Henson, Claire Paquet
1
137
Load more