youtu.be/J9EnUAZfmZg?si=WMCM… nflammation is evolutionarily conserved as an adaptive, short-term survival mechanism designed to eliminate pathogens, heal damaged tissue, and restore homeostatic equilibrium. However, when an inflammatory response fails to resolve, it can transition into a low-grade, non-infectious, and non-resolving state known as Systemic Chronic Inflammation (SCI). Unlike acute inflammation—which features classic localized symptoms like heat, pain, redness, and swelling—SCI is immunologically distinct, clinically silent, and systemically destructive. Over time, SCI damages healthy cells, tissues, and organs, serving as a primary driver for the majority of non-communicable, age-related chronic conditions. According to the Global Burden of Disease Study, these chronic inflammatory diseases collectively account for over 70% of all deaths worldwide.

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