🔅PTH and total ALP are heavily affected by renal and HD clearance.
🔅 bALP, PINP, and TRAP5b do not rely on renal or HD clearance for removal.
🔅This makes their specific high/low cut-off thresholds highly stable in advanced CKD.
#ERA26
🔅Combine strategic BTM panels with DXA BMD measurements.
🔅 This combined strategy dramatically improves the identification of high-risk patients.
#ERA26
🥳After months of preparation, coordination, and teamwork, the time has finally come.
🎉The ERA Staff has danced its way from Parma to Glasgow, and now they are ready for #ERA26.
💡Ready to challenge your thinking!
Thankyou @sciqst Great point—this gap is multifactorial:
• Hyperkalemia risk (real/perceived) ⚡
• Rise in creatinine → premature down-titration 📉
• Hypotension in advanced CKD 🩺
• Monitoringconstraints 🏥
New K⁺ binders closer monitoring may help bridge this.
Absolutely—this is where the field is evolving:
• 🧪 New K⁺ binders (patiromer, SZC) enabling RAASi continuation
• 💊 Non-steroidal MRAs (finerenone) with lower hyperkalemia risk
• 📊 AI/biomarker-driven risk prediction for early intervention
• 🎯 Personalized RAASi binder