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Bennett Lab @ebennettlab

The Bennett Lab specializes in all things related to ubiquitin and protein homeostasis

Joined October 2019
  • Tweets 60
  • Following 49
  • Followers 553
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Keystone Ubiquitin Biology/Targeted Protein degradation meeting is finally going to happen!! - Abstract Deadline is Sept 19 - Looking forward to catching up with old friends and making new ones keysym.us/KSUbiquitinBio22

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Believe it or not, the Keystone Ubiquitin Biology/Targeted Protein Degradation is finally happening!! Abstract deadline is Sept 19 - urldefense.com/v3/__keystone…$
Scholarship and Abstract deadlines are rapidly approaching for keysym.us/KSUbiquitinBio22. Looking forward to (hopefully) reconnecting with the ubiquitin field in person!!
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Working with a great team to organize @KeystoneSymp #Ubiquitin Biology in January. Connect with #ProteinDegradation #Proteasome field leaders in Vancouver! keysym.us/KSUbiquitinBio22 #KSUbiquitinBio22
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After a quiet 18 months on campus, it is great to see our undergrads back. The energy on campus is amazing.
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It is always a great day when one of your students defends their doctoral thesis. Congrats @DGarshott, now Dr. Garshott!! So proud.
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Danielle demonstrates RNF10 and USP10 regulate site-specific 40S ubiquitylation and that constitutive ubiquitylation leads to 40S degradation!!!
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Congrats to Danielle @DGarshott and our collaborators Wade Harper @jwadeharper1 and Heeseon An for putting together a compelling study.
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Our paper on identifying a new arm of the ribosome quality control pathway is out today. cell.com/cell-reports/fullte…

iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation

Garshott et al. show that ubiquitylation of 40S ribosomal proteins uS3 and uS5 occurs as a result of translation initiation inhibition due to proteotoxic stressors. RNF10 catalyzes these ubiquityla...

cell.com
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Bennett Lab retweeted
University of California Health@UofCAHealth
24 Aug 2021
.@UCSDMedSchool researchers unlock a way to keep lab-grown stem cells healthy, which is positive news for people who need bone marrow transplants when donor stem cells are not available. The approach may also help further aging research. ow.ly/nSpg50FR4Vi
Illustration showing the HSF1-mediated heat shock pathway that promotes proteostasis in hematopoietic stem cells in culture and during aging. Photo credit: Cell Press

ALT Illustration showing the HSF1-mediated heat shock pathway that promotes proteostasis in hematopoietic stem cells in culture and during aging. Photo credit: Cell Press
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Are people still excited about publishing their manuscripts on BioRxiv?
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I was a excited about the prospect of rapid publication of pre-prints on BioRxiv and have posted most of our work prior to publication. However, recent experience has altered my thinking on pre-print publication. I wonder if my experience is not normal.
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Bennett Lab retweeted
Moritz Hunkeler@moritzhunkeler
26 Jul 2021
Almost one full year after the preprint (🚽), we can finally present the final version of our HUWE1 manuscript! Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition cell.com/molecular-cell/full…

Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

Hunkeler et al. present the cryo-EM structure of HUWE1, a large HECT E3 ligase that forms a modular ring-shaped assembly with flexibly attached accessory domains. The influence of mutations associa...

cell.com
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Congrats Matt. Looking forward to future collaborative efforts.
Matt Daugherty@Daugherty_Lab
21 May 2021
Thank you to @BWFUND and to the selection committee! And a huge thank you to all of the folks in my lab and in our collaborating labs that made this happen! I'm thrilled and humbled to be part of such an amazing group of current and past investigators!
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Bennett Lab retweeted
Nambi. MBBS, PhD@EnamCam
13 Nov 2020
Read our latest work here. #RQC #ribosomes #ubiquityltion #proteostasis. A @ebennettlab @Daugherty_Lab collab. We identify a conditional requirement for ZNF598 during vaccinia infection. ISR suppression is the conditional requirement. thanks to all the @amitfulzele2006
bioRxiv@biorxivpreprint
13 Nov 2020
Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection biorxiv.org/cgi/content/shor… #bioRxiv
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Bennett Lab retweeted
Moritz Hunkeler@moritzhunkeler
27 Apr 2021
Excited for #cshlubiq to (virtually) start soon! Step by posters-#106 and #136 for some HUWE1/HECT discussions!
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Thought ribosome collisions occurred only during elongation? Check out our latest work - iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation biorxiv.org/content/10.1101/… - Congrats to @DGarshott #crushingit

iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation

Since multiple ribosomes can engage a single mRNA, nonuniform ribosome progression can result in collisions. Ribosome collisions during translation elongation elicit a multifaceted ribosome-associa...

biorxiv.org
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So very excited for Ananda Goldrath, @GoldrathLab @ucsdbiosciences, who was elected to the American Academy of Arts and Sciences!!! She exemplifies greatness as a scientist, educator, mentor, and university leader. Well-deserved congratulations!!
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Excellent conversation that highlights what a PI does beyond writing grant proposals. With so much negative reporting around the difficulty obtaining faculty jobs, it was good to see an excellent accounting of the amazing aspects of our jobs.
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