Joined May 2026
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Jun 9
Cagrilintide - 0.5mg Cagri is a whisper. 1mg is a full mute on food noise. Week two at 1mg and the difference is not a placebo. Amylin does things GLP-1 alone just doesn't. I tend to layer cag with Reta vs amping up reta and use it when I feel the need to mute the food noise. Shoo Shoo bad food! π€£
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𧡠𧡠Tirz Cagri, 3 weeks in. I told myself I'd wait for real data before posting. Here it is. π π
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Three weeks of data from my CGM and intake tracking:
Average daily calories: down ~18% from my Reta baseline without trying. Not intentional restriction β I just stopped being interested in food at the times I used to be.
Postprandial glucose spikes: flatter. Reta had already tightened this, but Cagri seems to be extending the curve. Less sharp, slower return.
RHR: 52β54 bpm consistently, which is where I want it. This was the problem on Reta. Three weeks in, it's holding. π π
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Still early. I'm not calling this a win yet β I want 6 weeks of data and a DEXA before I make any real claims about lean mass retention. But the appetite signal is not a vibe. It's in the numbers. Who else is running this combo? Curious what doses people are at and when you started noticing the shift. π π
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2006: "Who's your weed dealer"
2026: "Who's your chinese peptide dealer"
π€£π
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Everyone talks TRT. Almost nobody talks what happens when you add 4 IU HGH daily on top of it.
TRT stabilizes your hormone floor. HGH rebuilds what age actually took β muscle architecture, recovery, body comp.
Different mechanisms. One system. After 50, that combination changes the math entirely.
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Low-carb already raises your natural GLP-1. Add Tirz on top of that? You're stacking mechanisms, not overlapping them.
The guys eating garbage and taking the same dose aren't hitting the same ceiling. Diet isn't optional on GLP-1 β it's a multiplier.
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𧡠'Run BPC-157 for 4 weeks after an injury' is the peptide equivalent of 'take ibuprofen and rest.' Not wrong. Just the lowest-effort version of a much better idea. π
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The honest comparison: a 4-week injury protocol is a patch. A daily blend running alongside your full stack is a system. My connective tissue recovery between sessions is noticeably different than when I ran BPC-157 solo post-injury a few years back. Can't DEXA that β but I'm training 6 days a week in my mid-50s with zero chronic joint issues. That's the data point I care about. π
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Wolverine blend (TB-500 BPC-157, 500mcg) goes in every night before bed on top of the morning KLOW. The split matters β daytime for the anabolic/repair window around training, nighttime to keep the signaling going during recovery sleep. If you're still on the 'injury only' protocol, you're running a reactive strategy in a sport that rewards proactive ones. π
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Everyone's celebrating Survodutide's weight loss numbers. Cool. Nobody's asking what's actually being lost.
Triple agonist vs. dual β the real question is lean mass. And clinical trials aren't measuring it.
Get a DEXA. That's where the answer lives.
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𧡠SS-31: the pivotal human heart failure trial failed its primary endpoint. I know. I still run 5mg MonβFri. Here's the actual reasoning β not the hype version. π
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What I'm actually expecting from it: not magic, not muscle, not a measurable single-compound outcome. I'm running it for mitochondrial membrane protection over time β the same reason I run NAD and MOTS-c. None of these are going to show up on a DEXA scan labeled 'SS-31 contribution.' That's not how compounding mechanisms work. The question isn't 'did SS-31 move the needle alone?' It's 'is my mitochondrial environment better with it in the stack than without it?' π
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The honest answer is I don't know with certainty β nobody does yet at the human level. But the preclinical data on mitochondrial energetics is solid, the mechanism is real, and the risk profile is low. So it stays. 5mg MonβFri, pre-gym, alongside MOTS-c, NAD , and SLU-PP-332. If you're running SS-31 because someone told you it's proven β read EMBRACE. If you're running it because you understand the cardiolipin mechanism and you're playing a long game, that's a different conversation. π
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Jun 12
Daily subQ isn't a vibe. It's a lab result.
Daily SubQ dose = E2 managed, Test Levels have no huge peaks, no crashes, no 3-day crater waiting for the next shot.
Weekly IM is a rollercoaster with a 7-day ticket. The data doesn't care about the debate.
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