Essential developments, informed discussion, and data, without the ideology and infotainment.
Joined April 2020
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#COVID19: Researcher blows the whistle on #data integrity issues in #Pfizer #vaccine trial
Company falsified data, unblinded patients, employed inadequately trained vaccinators, was slow to follow up on #AdverseReactions reported in pivotal phase 3 trial
bmj.com/content/375/bmj.n263…
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Anti-spike antibody response to natural #SARS_CoV_2 infection in the general population
"We estimated antibody levels associated with protection against reinfection likely last 1.5-2 years on average"
nature.com/articles/s41467-0…
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Effect of early treatment with #fluvoxamine on risk of emergency care and hospitalisation among patients with #COVID19: TOGETHER randomised, platform clinical trial
Treatment with fluvoxamine among high-risk outpatients reduced need for hospitalisation
thelancet.com/journals/langl…
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Cardiac MRI Findings of #Myocarditis After #COVID19 #mRNA #Vaccination in Adolescents
5 patients, all males with age ranging from 16 to 19 years presented within 4 days of the second dose of #COVID19 #mRNA #vaccine without known prior #COVID-19
ajronline.org/doi/10.2214/AJ…
U of T researchers create mirror-image peptides that can neutralize #SARS_CoV_2
Researchers at the University of Toronto @uoft have created chemical compounds that can neutralize SARS-CoV-2 and several of its #variants.
utoronto.ca/news/u-t-researc…
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Computational Design of Potent D-Peptide Inhibitors of #SARS_CoV_2
The two best designs bound the RBD with affinities of 29 and 31 nM and blocked the infection of Vero cells by SARS-CoV-2 with IC50 values of 5.76 and 6.56 μM, respectively
pubs.acs.org/doi/abs/10.1021…
Identification of driver genes for critical forms of #COVID19 in a deeply phenotyped young patient cohort
"Among differentially expressed genes, we observed up-regulation of the metalloprotease ADAM9.
We identified ADAM9 as a driver of disease severity.
science.org/doi/10.1126/scit…
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The spike protein of #SARSCoV2 variant A.30 is heavily mutated and evades #vaccine-induced #antibodies with high efficiency
nature.com/articles/s41423-0…
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#SARSCoV2 infects human adipose tissue and elicits an inflammatory response consistent with severe #COVID19
"adipose tissue supports SARS-CoV-2 infection and pathogenic inflammation and may explain the link between #obesity and severe COVID-19"
biorxiv.org/content/10.1101/…
A review: #Antibody-dependent enhancement (#ADE) in #COVID19: The not so friendly side of #antibodies
Sub-neutralizing antibodies can facilitate uptake by macrophages that express FcR, with stimulation of macrophages and production of cytokines.
journals.sagepub.com/doi/ful…
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UK government secures groundbreaking #COVID19 #antivirals
The 2 antivirals are:
#Molnupiravir, UK government has secured 480,000 courses
PF-07321332/#ritonavir, UK government has secured 250,000 courses
gov.uk/government/news/uk-go…
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#Valneva Reports Positive Phase 3 Results for Inactivated, Adjuvanted #CovidVaccine Candidate VLA2001. Neutralizing antibody seroconversion rate is above 95%.
valneva.com/press-release/va…
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Asymptomatic #SARSCoV2 #Vaccine #Breakthrough (VBT) Infections in HCWs Identified Through Routine Universal Surveillance Testing
Systematic surveillance of #vaccinated HCWs uncovers many times more cases of VBT infection than symptom-based testing.
acpjournals.org/doi/full/10.…
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Evidence for Biological Age Acceleration and #Telomere Shortening in #COVID19 Survivors
DeltaAge acceleration is 10.45 ± 7.29 years ( 5.25 years above the range of normality) compared with 3.68 ± 8.17 years for the #Covid_19-free population.
mdpi.com/1422-0067/22/11/615…
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A monoclonal antibody that neutralizes #SARSCoV2 variants, SARS-CoV, and other sarbecoviruses
Antibody 2-36 neutralized not only all current VOCs and SARS-COV, but also a panel of bat and pangolin sarbecoviruses that can use human ACE2 as a receptor.
biorxiv.org/content/10.1101/…
Differential Effects of Antiseptic Mouth Rinses on #SARSCoV2 Infectivity In Vitro
A 5% (v/v) dilution of Colgate Peroxyl or povidone-iodine completely blocked viral infectivity. 50% (v/v) dilution of Listerine or CHG blocked viral infectivity completely.
mdpi.com/2076-0817/10/3/272
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Breastfeeding infants receive neutralizing #antibodies and #cytokines from mothers immunized with a #COVID19 #mRNA #vaccine
anti-RBD IgG and anti-RBD IgA was detected in 33% and 30% of infant stool samples, respectively
medrxiv.org/content/10.1101/…
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Association of #Vaccination With the Persistence of Post-#COVID Symptoms (PASC)
Study inc. 453 #Covid19 patients with #LongCovid, of which 324 (72%) were #vaccinated between baseline & 6-month visit.
Vaccination is not associated with improvement in PASC
papers.ssrn.com/sol3/papers.…
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