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@MartinShkreli the drug should stay out of the brain and should not easily enter normal nerves. It should mainly get into pain neurons when inflammation opens channels like TRPV1 or P2X. once inside it blocks Nav1.7 from the inner side. that way irritated pain fibers become quieter without shutting down pain everywhere.
Jun 16
you wannna be a hero in biopharma?
1) leave AI to software people
2) forget longevity
3) definitely ignore "peptides"
go solve Nav1.7
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@MartinShkreli Inflamed tissue can be part of the targeting. Liu et al., 2011 showed acidic conditions helped move QX-314 through TRPV1 into nociceptors. Injured tissue is often acidic. So we can use the disease environment as the trigger. this is the rationale for a charged Nav blocker that only enters activated pain neurons.
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McDonnell et al. tested PF-05089771, a selective Nav1.7 blocker meant to stay mostly outside the brain, against placebo and pregabalin in diabetic neuropathy.
The main endpoint was average pain score over the last 7 days of week 4. PF-05089771 didn’t beat placebo at 0.41 vs placebo while pregabalin (of course).
to me this makes the case that staying peripheral is not enough by itself. maybe the next version needs to load better into inflamed or overactive pain fibers @MartinShkreli
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With a standard scalp camera, you can get a rough hair count and hair-width assessment through TrichoLens.
It’s not meant to replace clinical evaluation, but it can help make scalp tracking more visual, consistent, and measurable over time all from the comfort of your own home.
tricholens.com
#trichology #dermatology #machinelearning #ai #hairloss
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Not a Chatbot Wrapper. Specialized Computer Vision.
TrichoLens uses computer vision designed around hair loss, scalp health, follicle counts, hair-width assessment, sebum patterns, skin findings, and oral hygiene imaging (yeah we just randomly included the last one there just because)
Instead of giving you generic photo feedback, it helps turn your images into structured observations so you can track changes better and have a more informed conversation with your provider.
tricholens.com
#HairLoss #ScalpHealth #Trichology #Dermatology #ComputerVision #AIHealth #HealthTech #DigitalHealth #HairGrowth #ScalpAnalysis
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@sarahoetomato as you can see, @anagenxyz / @HairDAO_ blocked me as soon as I showed you.
But if you have questions maybe you should buy their topical dut and see if the label is what I posted ? It’s your choice at the end of the day. But the ULO website is better.
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Also just take a look at their posts when it comes to “extended release oral minoxidil”. It seems they only did one study on one person (who is literally the cofounder). Which is cool!
But note the attempts to make it seem like they discovered this PK profile & not Veradermics? I think they clearly stole IP from veradermics and are desperately trying to pass it off as their own. They’re very likely to be sued soon.
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I became familiar with this technique in the #dermatology space. Recently at @folligenz we used related Raman-based technology to verify liposomal minoxidil sulfate crossing the stratum corneum which, to my knowledge, is the first-ever use of this approach for this molecule class.
Typical studies use franz diffusion cells on pig ears while we had actual human subjects and spatial mapping in human tissue. (Performed by CRO CTI-CERT).
#biotech #biohacking #research
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SESORS combines two ideas:
SERS = boosts weak Raman signals using gold nanoparticles.
SORS = collects Raman signals from deeper layers by measuring light at an offset from the laser entry point.
Together, this lets them pull chemical signals from beneath a surface barrier like skull bone.
The researchers then made a brain-tissue mimic using agarose gel, added gold nanoparticles, then added neurochemicals. A cat skull fragment was placed in front of the gel to test whether the signal could still be detected through bone.
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The question is if #finasteride and #dutasteride cross the blood brain barrier. Finasteride might. However, finasteride inhibits type 2 5AR. Type 1 5AR is abundant in the brain.
Fin barely inhibits type 1 and this is evidenced by its nM IC50 scores.
#dutasteride on the other hand inhibits both type 1 and 2 5AR. However it may be too large to cross the blood brain barrier (even if it’s lipophilic). Dut has a size of 528.5 Daltons.
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#postfinasteridesyndrome proposes that 5-alpha reductase inhibitors interact with brain neurosteroid by reducing the synthesis of allopregnanolone by way of 5ar inhibition. So a study using this technique on #finasteride & #dutasteride users could offer some new insights. #pfs
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They tested melatonin, serotonin, and epinephrine. These aren’t neurosteroids but the concept matters because the study shows that Raman-based methods can identify biologically relevant neurochemicals through a skull-like barrier. They also used PCA to separate the signal from the skull/bone layer versus the deeper neurochemical layer.
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