Living up to its NAME - "Anaplastic" - "Large cell" -"Lymphoma", involving a groin node. Along with melanoma, ALCL should always be kept in the differential of an odd-looking pleomorphic tumor with dispersed single cells. (FNA)

#OTD Jun 13, 1850: The American League of Colored Laborers (ALCL) held its inaugural meeting in NYC at the Zion's Church. Samuel Ringgold Ward as president, Frederick Douglass, vice president and Henry Bibb was secretary, marking the formation of the 1st Black labor union in the U.S. #History blackpast.org/african-americ…

🧬 EHA2026 | Precision Hematology 🎤 Speaker: Sarka Pospisilova 🧪 Topic: TP53 aberrations across ALL & T/NK-cell lymphomas 🚨 TP53 is not only a CLL biomarker It also defines high-risk biology in ALL and T/NK-cell lymphomas 🩸 In adult newly diagnosed ALL: TP53 mutation incidence ≈ 17.2% ⚠️ More frequent in: Older patients 👴 Ph-negative B-ALL 🧬 Median TP53 VAF ≈ 42% 📌 In Ph-negative B-ALL: TP53 mutations were reported in 28% vs 3% in others 🔥 High TP53 VAF ≥45% was linked to: Higher relapse risk 🔁 Poor survival ☠️ Especially in patients ≥60 years with Ph-negative B-ALL 🧬 High genetic-risk ALL may involve homozygous TP53 alterations 🧫 In r/r B-ALL treated with CD19 CAR-T: TP53 alterations were a strong adverse prognostic factor ⚠️ Precision pearl: In ALL, TP53 VAF matters—not only mutation positivity 🧬 TP53 aberrations in NK/T-cell lymphomas remain difficult because datasets are rare 📌 Extranodal NK/T-cell lymphoma, nasal type: TP53 mutations ≈ 20–50% Common del(17p) Aggressive biology 📌 Cutaneous T-cell lymphoma: TP53 mutations ≈ 30% Prognostic impact variable 📌 Adult T-cell leukemia/lymphoma: Higher TP53 mutation rate in acute subtype Associated with poor survival 📌 ALCL: TP53 mutations ≈ 5–8% in literature Up to 16% in presented cohort High p53 overexpression suggests additional mechanisms 🚨 In ALCL, TP53 mutation predicts shorter PFS HR ≈ 3.3 p <0.0007 💡 Clinical takeaway: TP53 disruption across lymphoid malignancies = adverse biology, treatment resistance risk, and need for precision diagnostics 🎯 Test wisely: mutation type, VAF, allelic state, p53 expression, and disease context #EHA2026 #PrecisionHematology #TP53 #ALL #BALL #CARTCellTherapy #TCellLymphoma #NKTLymphoma #ALCL #Hematology #KFSHRC #ESH