Thought research reproduction meant: Read paper → run code → verify results. Reality 🥲 Working through BioReason (DNA Qwen GRPO): broken imports, version mismatches, flash-attention/NVCC issues, Slurm debugging, config tuning… Fix one thing → another breaks.

BioReason: Incentivizing Multimodal Biological Reasoning within a DNA-LLM Model arxiv.org/abs/2505.23579

So excited to be part of the first ever Arc AIxBio Fellows cohort! the legends @genophoria , @pdhsu, and the whole @arcinstitute team, thank you for making this happen me, Parsa (@Radii2323), Arihant, and Ivy are gonna cook BioReason-Cell, the first multimodal cell reasoning model 🧬

4. BioReason-Cell is building a multimodal cell LLM that generates mechanistic reasoning, not just predictions.

🧵 Global biomedical AI has a 1.4B-person blind spot. I built a platform to fix it. DM me for collabs. #bioreason #genetics #ai #indiangenes #cure #ayurveda

bioreason makes me happy everyday not only because we wanna cure disease but mainly working w my middle school buddy (@adibvafa) and being mentored by fantastic @genophoria (who we used to see his photo in our high school's hall of fame) and legendary @pdhsu

Excited to be part of ChatGPT Futures Class of 2026 with my bro Parsa (@Radii2323)! OpenAI showed the world that LLMs can reason. We showed that they can reason in biology. BioReason-Pro, our protein reasoning model, has been used by 3,000 reasearchers across 19 countries. And all of it is because OpenAI shared the fruit of their research with the world. I'm now more confident than ever that Bio AI will be the greatest endavour of humanity.

Biology is shifting from science to engineering. 🧬 Powerful session by @BoWang87 from @UofT at #AACR26 on the "Digital Biology" revolution. Key takeaways: • 25.6M cell X-Atlas/Pisces for causality learning 📊 • BioReason-Pro to decode protein function 💻 • Foundation models enabling predictive biology 🚀 The next big revolution is here. 🧠✨ @AACR @OncoAlert @Xaira_Thera bioreason.net

Next in line at #AACR26 is Bo Wang (U of Toronto/Xaira) about the power of foundational models (trained with perturb seq data) to predict cell disease pathways (X Cell Ultra). 2nd part: Can we teach LLM models to understand protein function (BioReason Pro, open-source)?

Will speak at @AACR at San Diego about virtual cell and BioReason, and other AI applications in biomedicine! DM if you want to grab a coffee and chat about AI&Bio!

The velocity at Qwen team is just incredible! Our team were just playing around their recent small model series, now Qwen 3.6 Plus dropped and it's free on OpenRouter. Specifically designed for agentic workflow with 1M context window. 65K output tokens. 3x faster than Claude Opus 4.6 in early tests. Qwen 3.5 was capable but flaky—long reasoning chains, inconsistent outputs, needed babysitting. 3.6 Plus hits 10.0 consistency (up from 9.0) with zero flaky tests. Can’t wait to test Qwen 3.6 in both our on-device medical LLM project and BioReason-Pro! qwen.ai/blog?id=qwen3.6

BioReason-Pro was released less than 2 weeks ago, and the response has been incredible. Already, 1,300 users worldwide have signed up for the portal, and 3,000 proteins have been tested. We’re deeply grateful for all the thoughtful and constructive feedback. Today, we’re open-sourcing 223,000 protein reasoning traces from BioReason-Pro on @huggingface and hopefully our work can further facilitate more research into biological reasoning! Dataset: huggingface.co/datasets/wang… Try it here: app.bioreason.net

We have open-sourced 223,000 protein reasoning traces from BioReason-Pro on Hugging Face! huggingface.co/datasets/wang…

xAI / Twitter team follows him and he added ca to github also… We found our 1m runner Ge15WGNkMrjHeEW1oqJybeUmr2tghu4qtL6JVjoLpump Bo Wang 🔥 #5・@BoWang87 [🧠 491] Followers: 28K ・ 34 smart Tweets: 1.8K ・ 41.8 likes/tweet Mentions: 10 ・ 9 smart Ethos: 1205 ・ neutral 🤔 Joined: 13-09-2016 18:16 UTC Associate Prof @UofT | Building first Virtual Cell @Xaira_Thera | AI & Bio & Healthcare | Inventor of scGPT, MedSAM, BioReason | Opinions my own 🧬 Rewkang ⋅ pmarca ⋅ punk6529 ⋅ sershokunin ⋅ knowerofmarkets Open in Moni ⋅ Open on 𝕏 ・ ♻️ ✨ 🗑 Bo Wang 🔥 #5・@BoWang87 [🧠 491] Followers: 28K ・ 34 smart Tweets: 1.8K ・ 41.8 likes/tweet Mentions: 10 ・ 9 smart Ethos: 1205 ・ neutral 🤔 Joined: 13-09-2016 18:16 UTC Associate Prof @UofT | Building first Virtual Cell @Xaira_Thera | AI & Bio & Healthcare | Inventor of scGPT, MedSAM, BioReason | Opinions my own 🧬 Rewkang ⋅ pmarca ⋅ punk6529 ⋅ sershokunin ⋅ knowerofmarkets Open in Moni ⋅ Open on 𝕏 ・ ♻️ ✨ 🗑

@adibvafa BioReason-Pro could be a nice addition to this cool tool

My takeaway from watching project Hail Mary: bioreason pro could’ve prevented this 😐 did mfs even TRY prompting the worlds first reasoning model for biology?

We have fixed a major inference bug in bioreason.net, significantly improving the quality of reasoning Give BioReason-Pro another try! And please keep the feedback coming You can also find a guide on setting up the model locally at bioreason.net/code

I made a french podcast about #bioreason #pro Thanks for all your work and @BoWang87 on #Medicbrain #GoGPT open.spotify.com/episode/5Rz…