25 Sep 2018
Nir Barzilai starting a great final day @CellSymposia #CSAging on his work with centenarians & metformin met by none other than Prof.Kenyon on DAF-2 turndown to @wysscoray & VCAM1 inhibition, along with much more. Poster didn't do too bad either! @Einstein_Group @StanfordMed @NIH
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25 Sep 2018
#CSaging 2018 has been a great experience. So many interesting approaches to elucidating and preventing ageing. Thanks to everyone there for making it fun and educational.
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25 Sep 2018
.@AndersonRozalyn at #CSAging showing beautiful complex multi-omic data from primate CR. Transcription, RNA processing, translation, PTMs all affect same pathways but through different factors. Need to integrate ALL for true insight (as our cells do!). cell.com/cell-metabolism/abs…
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24 Sep 2018
Quality day @CellSymposia #CSAging discussing stem cells,periodic fasting,cell senescence & CD22!From @MPIAGE Bruning's work on POMC & AgRP with IR to @BuckInstitute @EricVerdin research into the NAD pathway topped off with an excellent meet the speakers dinner.Excited for day 3
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24 Sep 2018
Rising star John Pluvinage from @wysscoray lab along with the wonderful Benjie Smith from @CarolynBertozzi lab! #CSaging
24 Sep 2018
Finished day two with areally interesting talk on CD22. It also included some chemistry thanks to the @CarolynBertozzi lab. #CSaging
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24 Sep 2018
Finished day two with areally interesting talk on CD22. It also included some chemistry thanks to the @CarolynBertozzi lab. #CSaging
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24 Sep 2018
Thank you Judy Campisi for an incredible 30 minute seminar on the state of the art of senescence and SASP at #CSAging! 4 keys to SASP: 2 arms, heterogeneous, dynamic, specific to inducer. Lots to learn about dynamic changes over days-weeks-months.
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24 Sep 2018
Another great #CSAging talk in Sitges by Valter Longo on FMD. Thought provoking aud Q about role of BHB in FMD vs other KD. Valter suggests low energy of FMD helps BHB effects. Testable hypothesis, can ID mechanisms, and important for translation of BHB-derived therapeutics.
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24 Sep 2018
Genes for human longevity prove elusive - says Slagboom - no real progress in ten years since ApoE found and possibly Fox03- yet genes important in some families so need to use predictive blood metabolites in large cohorts #CSaging
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24 Sep 2018
Jens Bruning shows that mice that see edible food trigger brain changes that start producing key proteins in the liver as if they were really eating #CSAging
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24 Sep 2018
@jensbruning reminds us of the importance of the brain in glucose response and AgRP neutrons in the actuate nucleus of the brain in response to food and insulin resistance #CSAging
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24 Sep 2018
Looking forward to presenting poster86 1:30pm today on aging macrophages & inflammation #CSAging. Only possible thru funding by @DiabetesUK @TheBHF in collaboration with @UoL_LICAMM @unileedscardio. Also speaking @bsicongress Ageing & Immune System on Friday!
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23 Sep 2018
Poo transplants in African killfish show microbes and their metabolites can make fish live longer. Could be good news for humans who store poo samples when young @darissambaya #CSAging
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23 Sep 2018
Enjoying a fantastic local fish - a barat which is like a giant fat tastier mackerel full of good fats and vitamin D for longevity #CSAging
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23 Sep 2018
At #CSaging meeting in sitges discovering the secrets of eternal life and a secret Catalan Onion focaccia with anchovies that is a threat to the Genoese
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23 Sep 2018
After senescence and UPR, we are onto gutmicrobiome interactions. Very impressive and intersting so far. #CSaging
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23 Sep 2018
Quick shout out for my favorite human transposase, PGBD3. This old friend makes a fusion protein with ERCC6, a DNA repair chromatin remodeling gene that causes a premature aging disease. And its footprints are scattered throughout our genome. What does it do in aging? #CSAging
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23 Sep 2018
I love that SINEs and LINEs are back in the scientific spotlight - long live #transposons! John Sevidy now showing that the interferon response to uncontrolled LINE replication in senescent cells may be a trigger for SASP. #CSAging
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