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PEPEVOLVE: POSITION-AWARE DYNAMIC PEPTIDE OPTIMIZATION VIA GROUP-RELATIVE ADVANTAGE 1. A novel study introduces PepEVOLVE, a novel framework for optimizing macrocyclic peptides that dynamically identifies optimal editing sites and improves peptide properties through multi-objective optimization. 2. Unlike previous methods like PepINVENT that require pre-specifying mutable positions, PepEVOLVE uses a context-free multi-armed bandit router to automatically discover high-impact residues for modification, enhancing the efficiency and flexibility of peptide optimization. 3. The framework incorporates dynamic pretraining with strategies like dynamic masking and CHUCKLES shifting, which significantly improve the model's generalization ability and robustness to representational shifts in peptide sequences. 4. During optimization, PepEVOLVE employs an evolving algorithm that allows peptides to iteratively evolve, coupled with a group-relative advantage mechanism to stabilize reinforcement learning updates and explore diverse peptide design spaces. 5. In silico evaluations demonstrate PepEVOLVE's superior performance, achieving higher mean scores and identifying better candidates compared to PepINVENT, while converging faster under tasks like optimizing permeability and lipophilicity with structural constraints. 6. This work offers a practical and reproducible solution for peptide lead optimization when optimal edit sites are unknown, enabling more efficient exploration and improving design quality across multiple objectives, thus advancing computational peptide design. 📜Paper: arxiv.org/abs/2511.16912v1 #PepEVOLVE #PeptideOptimization #ComputationalBiology #DynamicOptimization #MachineLearning #DrugDiscovery
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Do not miss the deadline! Apply to the postdoc position at @ubeconomics with an incredible team, department, and faculty! 😍 #EconTwitter #Postdoc #EconJobMarket #EnvironmentalEconomics #MathematicalEconomics #DynamicOptimization #DynamicGames
Are you a PhD candidate or a PhD holder working in Mathematical Economics? Would you like to work at @UniBarcelona ? We are hiring a Postdoctoral Researcher in the Department of Economic, Financial and Actuarial Mathematics @ubfacecoiempres. More info to apply ⬇️
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Interested in #GameTheory, #EnvironmentalEconomics and/or #DynamicOptimization? You should apply to the #PostDoc at the University of Valladolid. Guiomar Martín-Herrán and Francisco Cabo are great researchers and amazing people! #EconTwitter @UVa_es @IMUVA_
23 Feb 2023
Job opening (postdoc position) at the University of Valladolid in dynamic optimization, game theory and/or environmental economics! For more information, please click here ➡️ imuva.uva.es/uploads/convoca… Deadline applications: February 28th
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22 Oct 2022
TigerStop products push, pull & position material to perfection. Contact us to learn about the innovative machinery and software solutions we offer: bit.ly/3mp81Pj #TigerStop #LeanManufacturing #Automation #LengthStop #DynamicOptimization #OptimizationSoftware
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19 Oct 2022
Take production to a whole new level with the product that started it all - the original #TigerStop. Turn your existing manual machine into a fully automatic #LeanManufacturing asset: bit.ly/33Bi3rc #Automation #LengthStop #DynamicOptimization #OptimizationSoftware
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ATMIA Europe 2022 Look forward to meeting you in Berlin next 19-20 October 2022. To book an appointment please contact sales@arutesolutions.com #ATMIA #ATMIAeurope2022 #bank #cashintransit #bank #cashmanagement #dynamicoptimization
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10 Sep 2022
Best-in-class solutions require more than physical products - they require smart software as well. Check out this short video of our #DownloadingSoftware, TigerLink6: bit.ly/3QumlCU #TigerStop #LeanManufacturing #Automation #CutListDownloading #DynamicOptimization
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Learn how the #DynamicOptimization technology in #AspenGDOT helps to close the loop between #planning and #advancedprocesscontrol. #APC #aspenONE #v11 #OPTIMIZE2019
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8 Mar 2016
G&E Cabinetry's Secret to Competing Globally hubs.ly/H02k8YM0 #TigerStop #Cabinetry #DynamicOptimization
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