SynHG (Synthetic Human Genome)
SynHG is aiming to develop the foundational & scalable tools, tech & methods needed to synthesise human genomes.
mrc-lmb.cam.ac.uk/sites/synh…
Constructive Bio
Uses the world’s first fully synthetic recoded organism to produce therapeutics w/ chemistries that natural biology cannot access.
constructive.bio/
Genetic Code Expansion Platform
The platform enables fermentation-based production of peptides & proteins containing hundreds of non-canonical amino acids.
Transform natural cells into programmable biofactories w/ expanded chemical capabilities.
constructive.bio/platform
BioForge
Constructive Bio’s industrial fermentation platform for manufacturing peptide & protein therapeutics containing up to 3 different non-canonical amino acids per molecule.
constructive.bio/bioforge
Non-canonical amino acids (ncAAs)
ncAAs expand the chemical properties available to peptides & proteins beyond the 20 standard amino acids.
BIOLOGY GIVES U 20 BUILDING BLOCKS. WE GIVE U HUNDREDS MORE!
We engineer orthogonal aminoacyl-tRNA synthetases (aaRS) that selectively charge non-canonical amino acids onto dedicated tRNAs. These engineered aaRS–tRNA pairs work alongside the cell's native translation machinery w/out cross-reacting, enabling site-specific incorporation of ncAAs into peptides & proteins during standard fermentation.
constructive.bio/ncaa
Pipeline
The pipeline applies the platform to novel peptide & protein therapeutics, from discovery to clinic.
Enabling robust, reliable bioproduction w/ our phage-resistant Syn61 platform for industrial-scale manufacturing.
Our Syn61 chassis provides inherent resistance to bacteriophage contamination, a critical advantage for industrial biomanufacturing where phage infection can cause catastrophic production failures.
constructive.bio/pipeline
Publications
constructive.bio/publication…
By combining fully synthetic genomes w/ precisely engineered genetic codes & orthogonal translation machinery, his teams are enabling cells to synthesise entirely new classes of molecules: polymers w/ properties unattainable by natural chemistry, sequence-defined non-canonical biopolymers, & therapeutics that operate far beyond the limits of ribosomal biosynthesis as we know it.
At the heart of the discussion stands Syn61 – now widely regarded as one of the landmark achievements in the history of genome engineering. Syn61 was the clearest demonstration to date that life can be liberated from the universal code that has governed biology for billions of years. It was followed by Syn57. Thru meticulous, genome-wide recoding, Chin’s team compressed the canonical 64-codon genetic code into a streamlined 57-codon framework. As a result, Syn57 is THE LARGEST DELIBERATE REWRITE OF A LIVING GENOME EVER ACCOMPLISHED.
As Chin explains, Syn61 & Syn57 are more than a technical tour de force – they demonstrate the foundational platform for a new era of biological programming. FREED CODONS CAN NOW BE REASSIGNED @ WILL, OPENING VAST CHEMICAL SPACE FOR INCORPORATING NON-CANONICAL AMINO ACIDS, creating genetic firewalls, & ultimately DESIGNING ORGANISMS WHOSE BIOCHEMISTRY OPERATES UNDER RULES WE DEFINE.
constructive.bio/news/synbio…
The tech begins w/ assembling large, synthetic DNA fragments that replace megabase-scale sections of an organism's natural genome. W/in these synthetic DNA constructs, specific redundant genetic codons are entirely removed. This frees up those codons & their associated cellular machinery—such as tRNAs & aminoacyl-tRNA synthetases. By introducing new tRNAs & synthetases, the cell's translational system is re-purposed to recognize these free codons & assign them to entirely new, non-natural monomers.
The result is a "recoded" organism capable of sustainably building unique polymers @ scale, extending far beyond nature's standard 20 amino acids. These non-canonical polymers can be endowed w/ enhanced properties in new materials & therapeutics.
synbiobeta.com/read/construc…