📢 #labspotlight | Dr. Sagar Sengupta's lab at BRIC-NIBMG Work from Dr. Sagar Sengupta’s lab, published in Nucleic Acids Research, uncovered a previously unknown feed-forward loop between ATM (ataxia-telangiectasia mutated) and the DNA repair protein BLM that helps promote and sustain DNA Damage Response (DDR) signaling. Importantly, the findings suggest that the phosphorylated BLM peptide could potentially be explored for delaying or preventing cancer. To read more: 🔗 academic.oup.com/nar/article… @DBTIndia @BricDbt @DrJitendraSingh @rajesh_gokhale @DrSagarSengupta #bricnibmg #nucleicacidsresearch #DNARepair #GenomeIntegrity #cancerresearch #DDR #translationalresearch

📢 #labspotlight - Dr. Sagar Sengupta's lab at BRIC-NIBMG Research from Dr. Sengupta's lab revealed how two proteins, RAD54 and BLM, work together to remodel chromatin and activate genes that help cancer cells pump anti-cancer drugs out of the cell, rendering treatment ineffective. Importantly, they identified three small molecules that disrupt the RAD54–BLM interaction thus restoring the effectiveness of the drugs. These regulatory-approved molecules hold strong promise as adjunct therapies for colon cancer. To read more : doi: 10.1172/JCI161941 @BricDbt @DBTIndia @DrJitendraSingh @rajesh_gokhale @DrSagarSengupta #bricnibmg #cancerresearch #ColonCancer #chemoresistance #DNARepair #translationalresearch #Genomics #AdjunctTherapy

🔬Lab Spotlight: Dr. Sagar Sengupta’s Lab at BRIC–NIBMG Dr. Sagar Sengupta’s lab is dedicated to understanding the maintenance of genome integrity in cancer and mitochondrial disorders. The group tackles fundamental biological questions while translating discoveries into meaningful biomedical applications. Their work bridges basic research and translational science, contributing to improved understanding of disease mechanisms and potential clinical impact. Stay tuned for more insights and innovations from Dr. Sengupta's team! @DBTIndia @BricDbt @DrJitendraSingh @rajesh_gokhale @DrSagarSengupta #BRICNIBMG #LabSpotlight #Genomics #CancerResearch #Mitochondria

Welcome to MISTRAS’ Phoenix Lab, Arizona’s trusted hub for fast, reliable NDT and chemical processing across the Aerospace & Defense Industry. We asked GM David Schmitt what makes Phoenix so special. Scroll below to find out. #MISTRAS #Phoenix #LabSpotlight #Aerospace

🔬 Lab Spotlight | Dr. Souvik Mukherjee’s Research Group At BRIC–NIBMG, the Human Microbiome Research (HMR) team led by Dr. Souvik Mukherjee is advancing research on how microbiome changes influence major health challenges in India. As part of this mission, the Diabetic Retinopathy Microbiome Study (DRMS)–India is being conducted in collaboration with @lvpei , Hyderabad. This large-scale, multi-centre effort involves approximately 500 participants — including healthy individuals, those with diabetes mellitus (DM), and those with diabetic retinopathy (DR) — recruited from 17 eye hospitals across India. India is among the top three countries globally in diabetes prevalence, and according to the International Diabetes Federation (IDF), the number of people with diabetes here is projected to increase by nearly 75% in the next 25 years. DR, the most common and earliest detectable microvascular complication of DM, can cause irreversible vision loss if left untreated. Our team’s work focuses on: 🔍 Identify gut microbiome differences that mark the progression from DM to DR. 🧮 Developing a clinic-friendly Microbial Index Score to assess DR risk and progression. 🧪 Design a probiotic-based intervention to slow or prevent the transition from DM to DR in the future. Through this collaborative initiative, BRIC–NIBMG aims to translate microbiome discoveries into accessible clinical tools for early detection and prevention, protecting vision and improving diabetes care. @DBTIndia @BricDbt @DrJitendraSingh @rajesh_gokhale @DrSagarSengupta @smlab_NIBMG #labspotlight #microbiome #diabeticretinopathy #diabetes #PublicHealth #Metagenomics #PrecisionMedicine

🔬 #LabSpotlight: Prof. Arindam Maitra’s lab explores oral cancer, preterm birth & gene regulation in human health using state-of-the-art single cell genomic, transcriptomic, epigenomic methods. @DBTIndia @DrSagarSengupta @DrJitendraSingh @rajesh_gokhale @MaitraArindam @BricDbt

#LabSpotlight At @FollowDbtNibmg, Dr Dilip Kumar’s team investigates therapeutic resistance in AML & colorectal cancer using systems biology & genomics data. Aiming to turn gene signatures into diagnostics & therapies @DBTIndia @DrJitendraSingh @DrSagarSengupta @rajesh_gokhale

#LabSpotlight Can you predict risk of oral cancer at precancer stage? Dr. Nidhan Biswas's team identified genomic drivers of oral cancer progression through integrative genomic & transcriptomic profiling Read in Journal of Pathology doi: 10.1002/path.5900 doi: 10.1002/path.5993

#LabSpotlight on Dr. Samsiddhi Bhattacharjee's lab 🔬Unlocking Complex Disease Mysteries with #MultiOmics🧬 His lab integrates genomic, transcriptomic, & proteomic data to decode disease mechanisms. They use models like Polygenic/Omnigenic architectures & GWAS 🖥️💡.

🌟#LabSpotlight: Dr. Samsiddhi Bhattacharjee’s Lab🌟 Dr. Bhattacharjee’s Ph.D. scholar, Mr. Gaurav R. Amle, is studying how transcription factors control genes in complex diseases.Using advanced models and public datasets,they identify gene switches affected by genetic variations

🌟#LabSpotlight: Dr. Samsiddhi Bhattacharjee’s Lab🌟 Dr. Bhattacharjee's Ph.D. scholar, Mr. Kallol Datta, leads research on modeling genomic risk for complex diseases using decision trees to study various interactions. @rajesh_gokhale @DrSagarSengupta #Genomics #complextraits

Don't miss the Yamazaki #LabSpotlight this week in #SimplyBlood🩸. Dr. Yamazaki candidly reflects on their distinctive career, offers advice to junior researchers, and more! simplyblood.org

This week on #SimplyBlood 🩸 we have a #LabSpotlight featuring @DaphnaNachmani Head to our blog to read about their recent research, biggest accomplishments, group celebrations, and more! simplyblood.org

Freddy is a PhD student using aerial drone footage to study the community dynamics of marine megafauna in Cabo Verde. His work has highlighted fascinating interactions and behaviors across the archipelago! 🚁🔎🐢🦈#CaboVerde #Conservation #LabSpotlight

James, a post-doc in the lab, delves into the genetic and epigenetic pathways guiding how loggerhead sea turtles may cope with climate change. Uncovering their adaptive potential is crucial for effective conservation strategies! 🌊🐢 #LabSpotlight #Conservation #SeaTurtles

The loggerhead turtle population in Cape Verde is growing, despite challenges. Fitra's research on associated environmental factors has uncovered intriguing links between historical temperatures and population dynamics! 🌡️📈🐢 #LabSpotlight #Conservation #SeaTurtles

Himmat is a master’s student looking into the sublethal effects of temperature on the fitness of sea turtle hatchlings. Specifically, he is investigating how DNA methylation may contribute to these sublethal effects. Exciting stuff!🧬🧬 #Methylation #Epigenetics #LabSpotlight

James joined the lab last month and it's exciting times ahead as he dives into the epigenetics of loggerhead turtles in Cape Verde, hoping to unlock insights that will enhance future conservation efforts!🧬🐢 #LabSpotlight #Conservation #SeaTurtles #Epigenetics

Lab Spotlight: DWJ Lab - Organic Chemistry🧪👩🔬 Willow Davis, a 3rd-year graduate student, works in the Darren W. Johnson Lab in the Chemistry Department. #ClassSpotlight #LabSpotlight

Find out how the Kulkarni Lab is working to mitigate the risk of acute lung injury in the latest #LabSpotlight in #The Microbiologist the-microbiologist.com/caree…