Valente S (Porto) PacBio vs ONT for diagnosing neurological repeat expansion disorders 🧬 Both were effective - PacBio more sensitive repeat genotyping, with spanning reads important - ONT offered greater flexibility for detecting additional variant types #ESHG2026

Moving into accuracy: Not every detected variant is a true variant. Lonneke shares a case where long-read genome sequencing revealed that an apparent LRP5 variant detected by short-read sequencing was actually just a sequencing artefact. #ESHG2026 #PacBio

Sharing results from a beta test of PacBio’s SPRQ-Nx reusable SMRT cells using two acquisitions! This increased SMRT cell throughput reduces sequencing costs for large human WGS projects. #ESHG2026 #PacBio #ESHG

SPRQ-Nx on Revio is built for true walk-away simplicity. SMRT Cells stay on the instrument and are entirely software managed. This automatic washing requires zero manual steps, leaving less time managing the instrument and more time on your science. #ESHG2026 #PacBio #SPRQNx

We are live at our #ESHG2026 Corporate Satellite Symposium! 🧬 Stay tuned as we share updates on how long-read population genomics is unlocking clinical impact today by scaling research and transforming patient outcomes. #PacBio

Day 1 at #ESHG2026 was incredible! Check out our Day 1 recap video to see what went down yesterday. 🎥👇 Onsite today? Don't forget to stop by our Corporate Satellite Symposium at 10:30 in Room A-5: "The power of long-read population genomics to unlock clinical impact."

The power of long-read sequencing lies not only in finding variants, but in understanding them. Through phasing, it resolves complex alleles, determines the origin of de novo variants, and detects mosaicism—providing actionable insights that streamline diagnostics. #ESHG2026

Can confirm Paraphase is awesome

To register, please visit: docs.google.com/forms/d/e/1F… Free hands-on practicals on PacBio Revio HiFi Sequencing practical session at inqaba biotec (by Inqaba Biotec, Pretoria, South Africa) Acclaim Moila @inqababiotec

SPRQ-Nx is shipping now! 🚀 This brings complete genomes at a completely new price with automated multi-use SMRT Cells, upgraded performance up to 48 genomes/week, and richer 5hmC multiomic data. #ESHG2026 #PacBio #SPRQNx

Bart van der Sanden now talks about how @PacBio and the specialized caller paraphrase helps in diagnosing patients with variants in paralogous genes. #eshg2026

Coming up today at 10:30 in Hall C: Don't miss Session C15.1! #PacBio Scientist Xiao Chen will showcase how HiFi sequencing resolves the complex D4Z4 repeat responsible for facioscapulohumeral muscular dystrophy. See you soon! #ESHG2026

When standard methods fall short, long reads deliver. Despite exome sequencing analysis, a genetic cause remained hidden. Long-read genome sequencing revealed a mobile element insertion in ADGRV1, solving this previously elusive case. #ESHG2026 #PacBio

Next up, Adam Ameur shares that long-read WGS efforts are ongoing in Sweden for population genomics and clinical diagnostics. They bridge these projects by using a joint analysis framework and shared variant databases. #ESHG2026 #PacBio #ESHG