Magnesium sulfate (MgSO₄)
Fascinating points about MgSO₄:
A remarkably versatile medication used across multiple specialties.
✅ Drug of choice for eclampsia/preeclampsia for seizure prevention and treatment
✅ Used in torsades de pointes (polymorphic VT), particularly in ACLS, even when serum magnesium is normal
✅ Treatment of hypomagnesemia
✅ Cardiac arrhythmias secondary to magnesium deficiency
✅ Acute severe asthma exacerbations (adjunct therapy)
✅ Tocolytic use in selected settings / fetal neuroprotection in specific obstetric contexts
✅ Constipation (oral magnesium salts)
How it works:
Magnesium is a divalent cation essential for ion transport and membrane stability. It modulates calcium influx through voltage-gated channels, stabilizes myocardial electrical activity, reduces neuromuscular excitability, and helps suppress early afterdepolarizations responsible for torsades
I’m a Drug, used in both
Torsades de Pointes and
Eclampsia.
Who am I?