Ferran Algaba Arrea, today in
#PuigvertinScience, about Urologic
#Pathology👇
“The journey of determining PD-L1 expression in muscle-invasive urothelial carcinoma:
Within the complex mechanism of antigen presentation to immune cells in order to destroy
#neoplastic cells, the latter are protected by PD-L1 molecules and are therefore targets for
#immunotherapy. Hence the determination of PD-L1 expression in tumor cells & immune cells is considered a marker for predicting treatment response.
👉In order to respond to all possible situations that may arise, now and in the future, the Spanish Society of
#AnatomicPathology @SEAP_IAP gathered a group of pathologists, together with a uro-oncologist, to draw up a
#guide of recommendations based on currently available evidence.
The questions I have tried to answer are:
🔘Which patients should be evaluated?
🔘Which sample is best for PD-L1 determination?
🔘Which antibody is best for invasive urothelial carcinoma?
🔘What to do if a first determination is negative?
🔘How should results be reported?”
🔗READ the article:
pubmed.ncbi.nlm.nih.gov/3875…
**Dr. Algaba is a well-known expert and national coordinator of Urologic Pathology at
@SEAP_IAP, Chief of Anatomic Pathology Lab of Fundació
#Puigvert